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Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic

Skeletal muscle injuries occur often in athletics and in daily life. In minor injuries, muscles are able to regenerate completely and recover their functional capabilities. However, in the case of severe injuries, the injured muscle cannot recover to a functional level because of the formation of fi...

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Detalles Bibliográficos
Autores principales: Gardner, Tyler, Kenter, Keith, Li, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745048/
https://www.ncbi.nlm.nih.gov/pubmed/33376749
http://dx.doi.org/10.1155/2020/7059057
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author Gardner, Tyler
Kenter, Keith
Li, Yong
author_facet Gardner, Tyler
Kenter, Keith
Li, Yong
author_sort Gardner, Tyler
collection PubMed
description Skeletal muscle injuries occur often in athletics and in daily life. In minor injuries, muscles are able to regenerate completely and recover their functional capabilities. However, in the case of severe injuries, the injured muscle cannot recover to a functional level because of the formation of fibrous scar tissue. The physical barrier of scars is significantly challenged in both research and clinical treatment. Fibrous scar tissue not only limits cells' migration, but also contributes to normal tissue biomechanical properties. This scar formation creates an unsuitable environment for tissue structure resulting in frequent pain. Antifibrosis treatment is one of the major strategies used to augment muscle regeneration and accelerate its functional recovery. This review will discuss the currently available methods for improving muscle regeneration with a specific focus on antifibrosis applications. We also discussed several novel hypotheses and clinical applications in muscle fibrosis treatment currently in practice.
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spelling pubmed-77450482020-12-28 Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic Gardner, Tyler Kenter, Keith Li, Yong J Sports Med (Hindawi Publ Corp) Review Article Skeletal muscle injuries occur often in athletics and in daily life. In minor injuries, muscles are able to regenerate completely and recover their functional capabilities. However, in the case of severe injuries, the injured muscle cannot recover to a functional level because of the formation of fibrous scar tissue. The physical barrier of scars is significantly challenged in both research and clinical treatment. Fibrous scar tissue not only limits cells' migration, but also contributes to normal tissue biomechanical properties. This scar formation creates an unsuitable environment for tissue structure resulting in frequent pain. Antifibrosis treatment is one of the major strategies used to augment muscle regeneration and accelerate its functional recovery. This review will discuss the currently available methods for improving muscle regeneration with a specific focus on antifibrosis applications. We also discussed several novel hypotheses and clinical applications in muscle fibrosis treatment currently in practice. Hindawi 2020-09-01 /pmc/articles/PMC7745048/ /pubmed/33376749 http://dx.doi.org/10.1155/2020/7059057 Text en Copyright © 2020 Tyler Gardner et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gardner, Tyler
Kenter, Keith
Li, Yong
Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic
title Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic
title_full Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic
title_fullStr Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic
title_full_unstemmed Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic
title_short Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic
title_sort fibrosis following acute skeletal muscle injury: mitigation and reversal potential in the clinic
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745048/
https://www.ncbi.nlm.nih.gov/pubmed/33376749
http://dx.doi.org/10.1155/2020/7059057
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