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Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic
Skeletal muscle injuries occur often in athletics and in daily life. In minor injuries, muscles are able to regenerate completely and recover their functional capabilities. However, in the case of severe injuries, the injured muscle cannot recover to a functional level because of the formation of fi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745048/ https://www.ncbi.nlm.nih.gov/pubmed/33376749 http://dx.doi.org/10.1155/2020/7059057 |
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author | Gardner, Tyler Kenter, Keith Li, Yong |
author_facet | Gardner, Tyler Kenter, Keith Li, Yong |
author_sort | Gardner, Tyler |
collection | PubMed |
description | Skeletal muscle injuries occur often in athletics and in daily life. In minor injuries, muscles are able to regenerate completely and recover their functional capabilities. However, in the case of severe injuries, the injured muscle cannot recover to a functional level because of the formation of fibrous scar tissue. The physical barrier of scars is significantly challenged in both research and clinical treatment. Fibrous scar tissue not only limits cells' migration, but also contributes to normal tissue biomechanical properties. This scar formation creates an unsuitable environment for tissue structure resulting in frequent pain. Antifibrosis treatment is one of the major strategies used to augment muscle regeneration and accelerate its functional recovery. This review will discuss the currently available methods for improving muscle regeneration with a specific focus on antifibrosis applications. We also discussed several novel hypotheses and clinical applications in muscle fibrosis treatment currently in practice. |
format | Online Article Text |
id | pubmed-7745048 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-77450482020-12-28 Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic Gardner, Tyler Kenter, Keith Li, Yong J Sports Med (Hindawi Publ Corp) Review Article Skeletal muscle injuries occur often in athletics and in daily life. In minor injuries, muscles are able to regenerate completely and recover their functional capabilities. However, in the case of severe injuries, the injured muscle cannot recover to a functional level because of the formation of fibrous scar tissue. The physical barrier of scars is significantly challenged in both research and clinical treatment. Fibrous scar tissue not only limits cells' migration, but also contributes to normal tissue biomechanical properties. This scar formation creates an unsuitable environment for tissue structure resulting in frequent pain. Antifibrosis treatment is one of the major strategies used to augment muscle regeneration and accelerate its functional recovery. This review will discuss the currently available methods for improving muscle regeneration with a specific focus on antifibrosis applications. We also discussed several novel hypotheses and clinical applications in muscle fibrosis treatment currently in practice. Hindawi 2020-09-01 /pmc/articles/PMC7745048/ /pubmed/33376749 http://dx.doi.org/10.1155/2020/7059057 Text en Copyright © 2020 Tyler Gardner et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Gardner, Tyler Kenter, Keith Li, Yong Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic |
title | Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic |
title_full | Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic |
title_fullStr | Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic |
title_full_unstemmed | Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic |
title_short | Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic |
title_sort | fibrosis following acute skeletal muscle injury: mitigation and reversal potential in the clinic |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745048/ https://www.ncbi.nlm.nih.gov/pubmed/33376749 http://dx.doi.org/10.1155/2020/7059057 |
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