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Discovery of highly selective and orally available benzimidazole-based phosphodiesterase 10 inhibitors with improved solubility and pharmacokinetic properties for treatment of pulmonary arterial hypertension

Optimization efforts were devoted to discover novel PDE10A inhibitors in order to improve solubility and pharmacokinetics properties for a long-term therapy against pulmonary arterial hypertension (PAH) starting from the previously synthesized inhibitor A. As a result, a potent and highly selective...

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Detalles Bibliográficos
Autores principales:	Yang, Yuncong, Zhang, Sirui, Zhou, Qian, Zhang, Chen, Gao, Yuqi, Wang, Hao, Li, Zhe, Wu, Deyan, Wu, Yinuo, Huang, Yi-You, Guo, Lei, Luo, Hai-Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745062/ https://www.ncbi.nlm.nih.gov/pubmed/33354505 http://dx.doi.org/10.1016/j.apsb.2020.04.003

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