Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5

Programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) blocking therapy has become a major pillar of cancer immunotherapy. Compared with antibodies targeting, small-molecule checkpoint inhibitors which have favorable pharmacokinetics are urgently needed. Here we identified berberine (...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Liu, Xiaojia, Zhang, Na, Yin, Mingxiao, Dong, Jingwen, Zeng, Qingxuan, Mao, Genxiang, Song, Danqing, Liu, Lu, Deng, Hongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745128/
https://www.ncbi.nlm.nih.gov/pubmed/33354502
http://dx.doi.org/10.1016/j.apsb.2020.06.014

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