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MendelianRandomization v0.5.0: updates to an R package for performing Mendelian randomization analyses using summarized data

The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data. In this manuscript, we describe functions that have been added to the package or updated in recent years. These features can b...

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Autores principales: Broadbent, Jim R., Foley, Christopher N., Grant, Andrew J., Mason, Amy M., Staley, James R., Burgess, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745186/
https://www.ncbi.nlm.nih.gov/pubmed/33381656
http://dx.doi.org/10.12688/wellcomeopenres.16374.2
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author Broadbent, Jim R.
Foley, Christopher N.
Grant, Andrew J.
Mason, Amy M.
Staley, James R.
Burgess, Stephen
author_facet Broadbent, Jim R.
Foley, Christopher N.
Grant, Andrew J.
Mason, Amy M.
Staley, James R.
Burgess, Stephen
author_sort Broadbent, Jim R.
collection PubMed
description The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data. In this manuscript, we describe functions that have been added to the package or updated in recent years. These features can be divided into four categories: robust methods for Mendelian randomization, methods for multivariable Mendelian randomization, functions for data visualization, and the ability to load data into the package seamlessly from the PhenoScanner web-resource. We provide examples of the graphical output produced by the data visualization commands, as well as syntax for obtaining suitable data and performing a Mendelian randomization analysis in a single line of code.
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spelling pubmed-77451862020-12-29 MendelianRandomization v0.5.0: updates to an R package for performing Mendelian randomization analyses using summarized data Broadbent, Jim R. Foley, Christopher N. Grant, Andrew J. Mason, Amy M. Staley, James R. Burgess, Stephen Wellcome Open Res Software Tool Article The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data. In this manuscript, we describe functions that have been added to the package or updated in recent years. These features can be divided into four categories: robust methods for Mendelian randomization, methods for multivariable Mendelian randomization, functions for data visualization, and the ability to load data into the package seamlessly from the PhenoScanner web-resource. We provide examples of the graphical output produced by the data visualization commands, as well as syntax for obtaining suitable data and performing a Mendelian randomization analysis in a single line of code. F1000 Research Limited 2020-12-10 /pmc/articles/PMC7745186/ /pubmed/33381656 http://dx.doi.org/10.12688/wellcomeopenres.16374.2 Text en Copyright: © 2020 Broadbent JR et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Software Tool Article
Broadbent, Jim R.
Foley, Christopher N.
Grant, Andrew J.
Mason, Amy M.
Staley, James R.
Burgess, Stephen
MendelianRandomization v0.5.0: updates to an R package for performing Mendelian randomization analyses using summarized data
title MendelianRandomization v0.5.0: updates to an R package for performing Mendelian randomization analyses using summarized data
title_full MendelianRandomization v0.5.0: updates to an R package for performing Mendelian randomization analyses using summarized data
title_fullStr MendelianRandomization v0.5.0: updates to an R package for performing Mendelian randomization analyses using summarized data
title_full_unstemmed MendelianRandomization v0.5.0: updates to an R package for performing Mendelian randomization analyses using summarized data
title_short MendelianRandomization v0.5.0: updates to an R package for performing Mendelian randomization analyses using summarized data
title_sort mendelianrandomization v0.5.0: updates to an r package for performing mendelian randomization analyses using summarized data
topic Software Tool Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745186/
https://www.ncbi.nlm.nih.gov/pubmed/33381656
http://dx.doi.org/10.12688/wellcomeopenres.16374.2
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