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Predicting EQ-5D-5L crosswalk from the PROMIS-29 profile for the United Kingdom, France, and Germany

BACKGROUND: EQ-5D health state utilities (HSU) are commonly used in health economics to compute quality-adjusted life years (QALYs). The EQ-5D, which is country-specific, can be derived directly or by mapping from self-reported health-related quality of life (HRQoL) scales such as the PROMIS-29 prof...

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Autores principales: Klapproth, Christoph Paul, van Bebber, J., Sidey-Gibbons, C. J., Valderas, J. M., Leplege, A., Rose, M., Fischer, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745375/
https://www.ncbi.nlm.nih.gov/pubmed/33334351
http://dx.doi.org/10.1186/s12955-020-01629-0
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author Klapproth, Christoph Paul
van Bebber, J.
Sidey-Gibbons, C. J.
Valderas, J. M.
Leplege, A.
Rose, M.
Fischer, F.
author_facet Klapproth, Christoph Paul
van Bebber, J.
Sidey-Gibbons, C. J.
Valderas, J. M.
Leplege, A.
Rose, M.
Fischer, F.
author_sort Klapproth, Christoph Paul
collection PubMed
description BACKGROUND: EQ-5D health state utilities (HSU) are commonly used in health economics to compute quality-adjusted life years (QALYs). The EQ-5D, which is country-specific, can be derived directly or by mapping from self-reported health-related quality of life (HRQoL) scales such as the PROMIS-29 profile. The PROMIS-29 from the Patient Reported Outcome Measures Information System is a comprehensive assessment of self-reported health with excellent psychometric properties. We sought to find optimal models predicting the EQ-5D-5L crosswalk from the PROMIS-29 in the United Kingdom, France, and Germany and compared the prediction performances with that of a US model. METHODS: We collected EQ-5D-5L and PROMIS-29 profiles and three samples representative of the general populations in the UK (n = 1509), France (n = 1501), and Germany (n = 1502). We used stepwise regression with backward selection to find the best models to predict the EQ-5D-5L crosswalk from all seven PROMIS-29 domains. We investigated the agreement between the observed and predicted EQ-5D-5L crosswalk in all three countries using various indices for the prediction performance, including Bland–Altman plots to examine the performance along the HSU continuum. RESULTS: The EQ-5D-5L crosswalk was best predicted in France (nRMSE(FRA) = 0.075, nMAE(FRA) = 0.052), followed by the UK (nRMSE(UK) = 0.076, nMAE(UK) = 0.053) and Germany (nRMSE(GER) = 0.079, nMAE(GER) = 0.051). The Bland–Altman plots show that the inclusion of higher-order effects reduced the overprediction of low HSU scores. CONCLUSIONS: Our models provide a valid method to predict the EQ-5D-5L crosswalk from the PROMIS-29 for the UK, France, and Germany.
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spelling pubmed-77453752020-12-18 Predicting EQ-5D-5L crosswalk from the PROMIS-29 profile for the United Kingdom, France, and Germany Klapproth, Christoph Paul van Bebber, J. Sidey-Gibbons, C. J. Valderas, J. M. Leplege, A. Rose, M. Fischer, F. Health Qual Life Outcomes Research BACKGROUND: EQ-5D health state utilities (HSU) are commonly used in health economics to compute quality-adjusted life years (QALYs). The EQ-5D, which is country-specific, can be derived directly or by mapping from self-reported health-related quality of life (HRQoL) scales such as the PROMIS-29 profile. The PROMIS-29 from the Patient Reported Outcome Measures Information System is a comprehensive assessment of self-reported health with excellent psychometric properties. We sought to find optimal models predicting the EQ-5D-5L crosswalk from the PROMIS-29 in the United Kingdom, France, and Germany and compared the prediction performances with that of a US model. METHODS: We collected EQ-5D-5L and PROMIS-29 profiles and three samples representative of the general populations in the UK (n = 1509), France (n = 1501), and Germany (n = 1502). We used stepwise regression with backward selection to find the best models to predict the EQ-5D-5L crosswalk from all seven PROMIS-29 domains. We investigated the agreement between the observed and predicted EQ-5D-5L crosswalk in all three countries using various indices for the prediction performance, including Bland–Altman plots to examine the performance along the HSU continuum. RESULTS: The EQ-5D-5L crosswalk was best predicted in France (nRMSE(FRA) = 0.075, nMAE(FRA) = 0.052), followed by the UK (nRMSE(UK) = 0.076, nMAE(UK) = 0.053) and Germany (nRMSE(GER) = 0.079, nMAE(GER) = 0.051). The Bland–Altman plots show that the inclusion of higher-order effects reduced the overprediction of low HSU scores. CONCLUSIONS: Our models provide a valid method to predict the EQ-5D-5L crosswalk from the PROMIS-29 for the UK, France, and Germany. BioMed Central 2020-12-17 /pmc/articles/PMC7745375/ /pubmed/33334351 http://dx.doi.org/10.1186/s12955-020-01629-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Klapproth, Christoph Paul
van Bebber, J.
Sidey-Gibbons, C. J.
Valderas, J. M.
Leplege, A.
Rose, M.
Fischer, F.
Predicting EQ-5D-5L crosswalk from the PROMIS-29 profile for the United Kingdom, France, and Germany
title Predicting EQ-5D-5L crosswalk from the PROMIS-29 profile for the United Kingdom, France, and Germany
title_full Predicting EQ-5D-5L crosswalk from the PROMIS-29 profile for the United Kingdom, France, and Germany
title_fullStr Predicting EQ-5D-5L crosswalk from the PROMIS-29 profile for the United Kingdom, France, and Germany
title_full_unstemmed Predicting EQ-5D-5L crosswalk from the PROMIS-29 profile for the United Kingdom, France, and Germany
title_short Predicting EQ-5D-5L crosswalk from the PROMIS-29 profile for the United Kingdom, France, and Germany
title_sort predicting eq-5d-5l crosswalk from the promis-29 profile for the united kingdom, france, and germany
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745375/
https://www.ncbi.nlm.nih.gov/pubmed/33334351
http://dx.doi.org/10.1186/s12955-020-01629-0
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