Electrosynthesis of Quinazolines and Quinazolinones via an Anodic Direct Oxidation C(sp(3))-H Amination/C-N Cleavage of Tertiary Amine in Aqueous Medium

[Image: see text] An electrochemical synthesis for quinazolines and quinazolinones was developed via a C(sp(3))-H amination/C-N cleavage by virtue of the anodic oxidation. The reaction can be carried out in aqueous media under mild conditions to afford the desired products with high yields. The reac...

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Detalles Bibliográficos
Autores principales: Zhou, Zhenghong, Hu, Kangfei, Wang, Jiawei, Li, Zhibin, Zhang, Yan, Zha, Zhenggen, Wang, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745442/
https://www.ncbi.nlm.nih.gov/pubmed/33344851
http://dx.doi.org/10.1021/acsomega.0c04865
Descripción
Sumario:[Image: see text] An electrochemical synthesis for quinazolines and quinazolinones was developed via a C(sp(3))-H amination/C-N cleavage by virtue of the anodic oxidation. The reaction can be carried out in aqueous media under mild conditions to afford the desired products with high yields. The reaction mechanism was proposed after detailed investigation.

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