Electrosynthesis of Quinazolines and Quinazolinones via an Anodic Direct Oxidation C(sp(3))-H Amination/C-N Cleavage of Tertiary Amine in Aqueous Medium

[Image: see text] An electrochemical synthesis for quinazolines and quinazolinones was developed via a C(sp(3))-H amination/C-N cleavage by virtue of the anodic oxidation. The reaction can be carried out in aqueous media under mild conditions to afford the desired products with high yields. The reac...

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Autores principales: Zhou, Zhenghong, Hu, Kangfei, Wang, Jiawei, Li, Zhibin, Zhang, Yan, Zha, Zhenggen, Wang, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745442/
https://www.ncbi.nlm.nih.gov/pubmed/33344851
http://dx.doi.org/10.1021/acsomega.0c04865
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author Zhou, Zhenghong
Hu, Kangfei
Wang, Jiawei
Li, Zhibin
Zhang, Yan
Zha, Zhenggen
Wang, Zhiyong
author_facet Zhou, Zhenghong
Hu, Kangfei
Wang, Jiawei
Li, Zhibin
Zhang, Yan
Zha, Zhenggen
Wang, Zhiyong
author_sort Zhou, Zhenghong
collection PubMed
description [Image: see text] An electrochemical synthesis for quinazolines and quinazolinones was developed via a C(sp(3))-H amination/C-N cleavage by virtue of the anodic oxidation. The reaction can be carried out in aqueous media under mild conditions to afford the desired products with high yields. The reaction mechanism was proposed after detailed investigation.
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spelling pubmed-77454422020-12-18 Electrosynthesis of Quinazolines and Quinazolinones via an Anodic Direct Oxidation C(sp(3))-H Amination/C-N Cleavage of Tertiary Amine in Aqueous Medium Zhou, Zhenghong Hu, Kangfei Wang, Jiawei Li, Zhibin Zhang, Yan Zha, Zhenggen Wang, Zhiyong ACS Omega [Image: see text] An electrochemical synthesis for quinazolines and quinazolinones was developed via a C(sp(3))-H amination/C-N cleavage by virtue of the anodic oxidation. The reaction can be carried out in aqueous media under mild conditions to afford the desired products with high yields. The reaction mechanism was proposed after detailed investigation. American Chemical Society 2020-12-01 /pmc/articles/PMC7745442/ /pubmed/33344851 http://dx.doi.org/10.1021/acsomega.0c04865 Text en © 2020 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle Zhou, Zhenghong
Hu, Kangfei
Wang, Jiawei
Li, Zhibin
Zhang, Yan
Zha, Zhenggen
Wang, Zhiyong
Electrosynthesis of Quinazolines and Quinazolinones via an Anodic Direct Oxidation C(sp(3))-H Amination/C-N Cleavage of Tertiary Amine in Aqueous Medium
title Electrosynthesis of Quinazolines and Quinazolinones via an Anodic Direct Oxidation C(sp(3))-H Amination/C-N Cleavage of Tertiary Amine in Aqueous Medium
title_full Electrosynthesis of Quinazolines and Quinazolinones via an Anodic Direct Oxidation C(sp(3))-H Amination/C-N Cleavage of Tertiary Amine in Aqueous Medium
title_fullStr Electrosynthesis of Quinazolines and Quinazolinones via an Anodic Direct Oxidation C(sp(3))-H Amination/C-N Cleavage of Tertiary Amine in Aqueous Medium
title_full_unstemmed Electrosynthesis of Quinazolines and Quinazolinones via an Anodic Direct Oxidation C(sp(3))-H Amination/C-N Cleavage of Tertiary Amine in Aqueous Medium
title_short Electrosynthesis of Quinazolines and Quinazolinones via an Anodic Direct Oxidation C(sp(3))-H Amination/C-N Cleavage of Tertiary Amine in Aqueous Medium
title_sort electrosynthesis of quinazolines and quinazolinones via an anodic direct oxidation c(sp(3))-h amination/c-n cleavage of tertiary amine in aqueous medium
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745442/
https://www.ncbi.nlm.nih.gov/pubmed/33344851
http://dx.doi.org/10.1021/acsomega.0c04865
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