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Conduct disorder and somatic health in children: a nationwide genetically sensitive study

BACKGROUND: Conduct disorder (CD), a serious behavioral and emotional disorder in childhood and adolescence, characterized by disruptive behavior and breaking societal rules. Studies have explored the overlap of CD with neurodevelopmental problems (NDP). The somatic health of children with NDP has b...

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Autores principales: Kerekes, Nóra, Zouini, Btissame, Karlsson, Emma, Cederholm, Emma, Lichtenstein, Paul, Anckarsäter, Henrik, Råstam, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745474/
https://www.ncbi.nlm.nih.gov/pubmed/33334305
http://dx.doi.org/10.1186/s12888-020-03003-2
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author Kerekes, Nóra
Zouini, Btissame
Karlsson, Emma
Cederholm, Emma
Lichtenstein, Paul
Anckarsäter, Henrik
Råstam, Maria
author_facet Kerekes, Nóra
Zouini, Btissame
Karlsson, Emma
Cederholm, Emma
Lichtenstein, Paul
Anckarsäter, Henrik
Råstam, Maria
author_sort Kerekes, Nóra
collection PubMed
description BACKGROUND: Conduct disorder (CD), a serious behavioral and emotional disorder in childhood and adolescence, characterized by disruptive behavior and breaking societal rules. Studies have explored the overlap of CD with neurodevelopmental problems (NDP). The somatic health of children with NDP has been investigated; however, the prevalence of these problems in children with CD has not been sufficiently studied. Holistic assessment of children with CD is required for establishing effective treatment strategies. Aims: (1) Define the prevalence of selected neurological problems (migraine and epilepsy) and gastrointestinal problems (celiac disease, lactose intolerance, diarrhea, and constipation) in a population of twins aged 9 or 12; (2) Compare the prevalence of somatic problems in three subpopulations: (a) children without CD or NDP, (b) children with CD, and (c) children with both CD and NDP; (3) Select twin pairs where at least one child screened positive for CD but not NDP (proband) and map both children’s neurological and gastrointestinal problems. METHOD: Telephone interviews with parents of 20,302 twins in a cross-sectional, nationwide, ongoing study. According to their scores on the Autism-Tics, AD/HD, and Comorbidities inventory, screen-positive children were selected and divided into two groups: (1) children with CD Only, (2) children with CD and at least one NDP. RESULTS: Children with CD had an increased prevalence of each neurological and gastrointestinal problem (except celiac disease), and the prevalence of somatic problems was further increased among children with comorbid CD and NDP. The presence of CD (without NDP) increased the odds of constipation for girls and the odds of epilepsy for boys. Girls with CD generally had more coexisting gastrointestinal problems than boys with CD. Female co-twins of probands with CD were strongly affected by gastrointestinal problems. Concordance analyses suggested genetic background factors in neurological and gastrointestinal problems, but no common etiology with CD could be concluded. CONCLUSION: Co-occurring NDP could explain most of the increased prevalence of somatic problems in CD. Our results raise a new perspective on CD in children and adolescents; their CD seems to be linked to a number of other health problems, ranging from neurodevelopmental and psychiatric disorders to somatic complaints.
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spelling pubmed-77454742020-12-18 Conduct disorder and somatic health in children: a nationwide genetically sensitive study Kerekes, Nóra Zouini, Btissame Karlsson, Emma Cederholm, Emma Lichtenstein, Paul Anckarsäter, Henrik Råstam, Maria BMC Psychiatry Research Article BACKGROUND: Conduct disorder (CD), a serious behavioral and emotional disorder in childhood and adolescence, characterized by disruptive behavior and breaking societal rules. Studies have explored the overlap of CD with neurodevelopmental problems (NDP). The somatic health of children with NDP has been investigated; however, the prevalence of these problems in children with CD has not been sufficiently studied. Holistic assessment of children with CD is required for establishing effective treatment strategies. Aims: (1) Define the prevalence of selected neurological problems (migraine and epilepsy) and gastrointestinal problems (celiac disease, lactose intolerance, diarrhea, and constipation) in a population of twins aged 9 or 12; (2) Compare the prevalence of somatic problems in three subpopulations: (a) children without CD or NDP, (b) children with CD, and (c) children with both CD and NDP; (3) Select twin pairs where at least one child screened positive for CD but not NDP (proband) and map both children’s neurological and gastrointestinal problems. METHOD: Telephone interviews with parents of 20,302 twins in a cross-sectional, nationwide, ongoing study. According to their scores on the Autism-Tics, AD/HD, and Comorbidities inventory, screen-positive children were selected and divided into two groups: (1) children with CD Only, (2) children with CD and at least one NDP. RESULTS: Children with CD had an increased prevalence of each neurological and gastrointestinal problem (except celiac disease), and the prevalence of somatic problems was further increased among children with comorbid CD and NDP. The presence of CD (without NDP) increased the odds of constipation for girls and the odds of epilepsy for boys. Girls with CD generally had more coexisting gastrointestinal problems than boys with CD. Female co-twins of probands with CD were strongly affected by gastrointestinal problems. Concordance analyses suggested genetic background factors in neurological and gastrointestinal problems, but no common etiology with CD could be concluded. CONCLUSION: Co-occurring NDP could explain most of the increased prevalence of somatic problems in CD. Our results raise a new perspective on CD in children and adolescents; their CD seems to be linked to a number of other health problems, ranging from neurodevelopmental and psychiatric disorders to somatic complaints. BioMed Central 2020-12-17 /pmc/articles/PMC7745474/ /pubmed/33334305 http://dx.doi.org/10.1186/s12888-020-03003-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Kerekes, Nóra
Zouini, Btissame
Karlsson, Emma
Cederholm, Emma
Lichtenstein, Paul
Anckarsäter, Henrik
Råstam, Maria
Conduct disorder and somatic health in children: a nationwide genetically sensitive study
title Conduct disorder and somatic health in children: a nationwide genetically sensitive study
title_full Conduct disorder and somatic health in children: a nationwide genetically sensitive study
title_fullStr Conduct disorder and somatic health in children: a nationwide genetically sensitive study
title_full_unstemmed Conduct disorder and somatic health in children: a nationwide genetically sensitive study
title_short Conduct disorder and somatic health in children: a nationwide genetically sensitive study
title_sort conduct disorder and somatic health in children: a nationwide genetically sensitive study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745474/
https://www.ncbi.nlm.nih.gov/pubmed/33334305
http://dx.doi.org/10.1186/s12888-020-03003-2
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