Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus-associated malignancies

BACKGROUND: Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of transforming growth factor (TGF)-βRII (a TGF-β ‘trap’) fused to a human IgG1 mAb blocking programmed cell death ligand 1. This is the largest analysis of patients with advanced, pretre...

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Detalles Bibliográficos
Autores principales: Strauss, Julius, Gatti-Mays, Margaret E, Cho, Byoung Chul, Hill, Andrew, Salas, Sébastien, McClay, Edward, Redman, Jason M, Sater, Houssein A, Donahue, Renee N, Jochems, Caroline, Lamping, Elizabeth, Burmeister, Andrea, Marté, Jennifer L, Cordes, Lisa M, Bilusic, Marijo, Karzai, Fatima, Ojalvo, Laureen S, Jehl, Genevieve, Rolfe, P Alexander, Hinrichs, Christian S, Madan, Ravi A, Schlom, Jeffrey, Gulley, James L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745517/
https://www.ncbi.nlm.nih.gov/pubmed/33323462
http://dx.doi.org/10.1136/jitc-2020-001395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745517/
https://www.ncbi.nlm.nih.gov/pubmed/33323462
http://dx.doi.org/10.1136/jitc-2020-001395

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