Cargando…

Non-invasive testing for liver pathology in alpha-1 antitrypsin deficiency

BACKGROUND: Many patients with alpha-1 antitrypsin deficiency (A1ATD) receive care in respiratory clinics without access to specialist hepatology expertise. Liver disease can develop asymptomatically, and non-invasive markers of fibrosis may help identify patients who require definitive assessment w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abbas, Syed Hamza, Pickett, Elisha, Lomas, David A, Thorburn, Douglas, Gooptu, Bibek, Hurst, John R, Marshall, Aileen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Biomarkers of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745521/ https://www.ncbi.nlm.nih.gov/pubmed/33323365 http://dx.doi.org/10.1136/bmjresp-2020-000820

Ejemplares similares

Alpha-1-Antitrypsin Deficiency, the Serpinopathies and Conformational Disease
por: Parmar, Jas S, et al.
Publicado: (2000)

Relationship of CT densitometry to lung physiological parameters and health status in alpha-1 antitrypsin deficiency: initial report of a centralised database of the NIHR rare diseases translational research collaborative
por: Crossley, Diana, et al.
Publicado: (2020)

Therapeutic target-site variability in α(1)-antitrypsin characterized at high resolution
por: Patschull, Anathe O. M., et al.
Publicado: (2011)

Metabolomics of World Trade Center-Lung Injury: a machine learning approach
por: Crowley, George, et al.
Publicado: (2018)

Three New Alpha1-Antitrypsin Deficiency Variants Help to Define a C-Terminal Region Regulating Conformational Change and Polymerization
por: Fra, Anna M., et al.
Publicado: (2012)

Comparison of COVID-19 Outcomes With Alpha-1 Antitrypsin Deficiency Prevalence in Europe: A Cross-Sectional Study
por: Sezgin, Yılmaz, et al.
Publicado: (2023)

Comparison of fibulin-3 and mesothelin as markers in malignant mesothelioma
por: Creaney, Jenette, et al.
Publicado: (2014)

The Its Not JUST Idiopathic pulmonary fibrosis Study (INJUSTIS): description of the protocol for a multicentre prospective observational cohort study identifying biomarkers of progressive fibrotic lung disease
por: Khan, Fasihul, et al.
Publicado: (2019)

Performance evaluation of human cough annotators: optimal metrics and sex differences
por: Sanchez-Olivieri, Isabel, et al.
Publicado: (2023)

Mineralization of alpha-1-antitrypsin inclusion bodies in Mmalton alpha-1-antitrypsin deficiency
por: Callea, Francesco, et al.
Publicado: (2018)

Liver Disease in Alpha-1 Antitrypsin Deficiency: Current Approaches and Future Directions
por: Mitchell, Ellen L., et al.
Publicado: (2017)

In Silico Assessment of Potential Druggable Pockets on the Surface of α(1)-Antitrypsin Conformers
por: Patschull, Anathe O. M., et al.
Publicado: (2012)

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway
por: Haq, Imran, et al.
Publicado: (2013)

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway
por: Haq, Imran, et al.
Publicado: (2013)

Gene therapy for alpha 1-antitrypsin deficiency with an oxidant-resistant human alpha 1-antitrypsin
por: Sosulski, Meredith L., et al.
Publicado: (2020)

Alpha-1 Antitrypsin as a Therapeutic Agent for Conditions not Associated with Alpha-1 Antitrypsin Deficiency
por: Wanner, Adam
Publicado: (2015)

Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency
por: Petrache, Irina, et al.
Publicado: (2009)

alpha1-Antitrypsin deficiency and hepatocellular cancer.
por: Kew, M. C., et al.
Publicado: (1978)

The prevalence of alpha-1 antitrypsin deficiency in Ireland
por: Carroll, Tomás P, et al.
Publicado: (2011)

Alpha-1 Antitrypsin Deficiency: The Learning Goes On
por: Stockley, Robert. A.
Publicado: (2020)

Monocytes and Macrophages in Alpha-1 Antitrypsin Deficiency
por: Belchamber, Kylie B R, et al.
Publicado: (2020)

Alpha-1 Antitrypsin Deficiency: Home Therapy
por: Annunziata, Anna, et al.
Publicado: (2021)

Polymers and inflammation: disease mechanisms of the serpinopathies
por: Gooptu, Bibek, et al.
Publicado: (2008)

Crystallographic and Cellular Characterisation of Two Mechanisms Stabilising the Native Fold of α(1)-Antitrypsin: Implications for Disease and Drug Design
por: Gooptu, Bibek, et al.
Publicado: (2009)

(1)H, (15)N and (13)C backbone resonance assignments of the archetypal serpin α(1)-antitrypsin
por: Nyon, Mun Peak, et al.
Publicado: (2011)

Alpha 1 antitrypsin to treat lung disease in alpha 1 antitrypsin deficiency: recent developments and clinical implications
por: Chapman, Kenneth R, et al.
Publicado: (2018)

Structural characterization and conformational dynamics of alpha-1 antitrypsin pathogenic variants causing alpha-1-antitrypsin deficiency
por: Shaik, Noor Ahmad, et al.
Publicado: (2022)

The role of bronchial epithelial cells in the pathogenesis of COPD in Z-alpha-1 antitrypsin deficiency
por: Pini, Laura, et al.
Publicado: (2014)

The Induction of Alpha-1 Antitrypsin by Vitamin D in Human T Cells Is TGF-β Dependent: A Proposed Anti-inflammatory Role in Airway Disease
por: Chen, Yin-Huai, et al.
Publicado: (2021)

alpha 1-Antitrypsin deficiency and susceptibility to lung disease.
por: Evans, H E, et al.
Publicado: (1979)

Alpha 1 Antitrypsin Deficiency in Infants with Neonatal Cholestasis
por: Monajemzadeh, Maryam, et al.
Publicado: (2013)

Cardiovascular risk in patients with alpha-1-antitrypsin deficiency
por: Fähndrich, Sebastian, et al.
Publicado: (2017)

The Importance of Early Identification of Alpha-1 Antitrypsin Deficiency
por: Buttar, Barjinder S, et al.
Publicado: (2018)

Severe bilateral descemetoceles in Alpha-1 antitrypsin deficiency
por: Ma, Jeffrey, et al.
Publicado: (2019)

Alpha-1 Antitrypsin Deficiency and COVID-19 Infection
por: Strassmair, Michael, et al.
Publicado: (2021)

Improving the Lives of Patients with Alpha-1 Antitrypsin Deficiency
por: Sandhaus, Robert A, et al.
Publicado: (2020)

Stem cell-based therapy for α(1)-antitrypsin deficiency
por: Rashid, S Tamir, et al.
Publicado: (2012)

Characterisation of a type II functionally-deficient variant of alpha-1-antitrypsin discovered in the general population
por: Laffranchi, Mattia, et al.
Publicado: (2019)

The structural basis for Z α(1)-antitrypsin polymerization in the liver
por: Faull, Sarah V., et al.
Publicado: (2020)

hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α(1)-antitrypsin deficiency
por: Segeritz, Charis-Patricia, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_gsspi43itt6jmpqnksgeiecur6