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Inhibition of ornithine decarboxylase restores hypoxic pulmonary vasoconstriction in endotoxemic mice

Endotoxemia impairs hypoxic pulmonary vasoconstriction which leads to systemic hypoxemia. This derogation is attributable to increased activity of nitric oxide synthase 2 and arginase metabolism. Gene expression analysis has shown increased expression of ornithine decarboxylase in lungs of endotoxem...

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Detalles Bibliográficos
Autores principales:	Gebauer, P.H., Turzo, M., Lasitschka, F., Weigand, M.A., Busch, C.J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2020
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745575/ https://www.ncbi.nlm.nih.gov/pubmed/33403098 http://dx.doi.org/10.1177/2045894020915831

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