4-1BB co-stimulation further enhances anti-PD-1-mediated reinvigoration of exhausted CD39(+) CD8 T cells from primary and metastatic sites of epithelial ovarian cancers

BACKGROUND: Responses to immunotherapy vary between different cancer types and sites. Here, we aimed to investigate features of exhaustion and activation in tumor-infiltrating CD8 T cells at both the primary and metastatic sites in epithelial ovarian cancer. METHODS: Tumor tissues and peripheral blo...

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Detalles Bibliográficos
Autores principales: Leem, Galam, Park, Junsik, Jeon, Minwoo, Kim, Eui-Soon, Kim, Sang Wun, Lee, Yong Jae, Choi, Seong Jin, Choi, Baekgyu, Park, Seongyeol, Ju, Young Seok, Jung, Inkyung, Kim, Sunghoon, Shin, Eui-Cheol, Lee, Jung Yun, Park, Su-Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745695/
https://www.ncbi.nlm.nih.gov/pubmed/33335029
http://dx.doi.org/10.1136/jitc-2020-001650

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