An overview on prostate-specific membrane antigen uptake in malignancies other than prostate cancer: A pictorial essay

Prostate-specific membrane antigen (PSMA) is a Type II transmembrane glycoprotein which is extremely overexpressed in prostate cancer epithelial cells. Recently, PSMA-targeted small molecule labeled with (68)Ga and (99m)Tc allowed precise molecular imaging of prostate cancer and PSMA-targeted small...

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Detalles Bibliográficos
Autores principales: Jafari, Esmail, Ahmadzadehfar, Hojjat, Dadgar, Habibollah, Assadi, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745855/
https://www.ncbi.nlm.nih.gov/pubmed/33354182
http://dx.doi.org/10.4103/wjnm.WJNM_78_19
Descripción
Sumario:Prostate-specific membrane antigen (PSMA) is a Type II transmembrane glycoprotein which is extremely overexpressed in prostate cancer epithelial cells. Recently, PSMA-targeted small molecule labeled with (68)Ga and (99m)Tc allowed precise molecular imaging of prostate cancer and PSMA-targeted small molecule labeled with 177Lu leads to the development of radionuclide-targeted therapy of prostate cancer. Despite its name, it has been shown that PSMA has been expressed in several malignancies which can be due to significant neovascularization. Present pictorial assay reports the nonspecific tracer uptake in some malignancies during (68)Ga-PSMA positron-emission tomography/computed tomography imaging and (99m)Tc-PSMA scintigraphy.

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