An overview on prostate-specific membrane antigen uptake in malignancies other than prostate cancer: A pictorial essay

Prostate-specific membrane antigen (PSMA) is a Type II transmembrane glycoprotein which is extremely overexpressed in prostate cancer epithelial cells. Recently, PSMA-targeted small molecule labeled with (68)Ga and (99m)Tc allowed precise molecular imaging of prostate cancer and PSMA-targeted small...

Descripción completa

Detalles Bibliográficos
Autores principales: Jafari, Esmail, Ahmadzadehfar, Hojjat, Dadgar, Habibollah, Assadi, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745855/
https://www.ncbi.nlm.nih.gov/pubmed/33354182
http://dx.doi.org/10.4103/wjnm.WJNM_78_19
_version_ 1783624685179633664
author Jafari, Esmail
Ahmadzadehfar, Hojjat
Dadgar, Habibollah
Assadi, Majid
author_facet Jafari, Esmail
Ahmadzadehfar, Hojjat
Dadgar, Habibollah
Assadi, Majid
author_sort Jafari, Esmail
collection PubMed
description Prostate-specific membrane antigen (PSMA) is a Type II transmembrane glycoprotein which is extremely overexpressed in prostate cancer epithelial cells. Recently, PSMA-targeted small molecule labeled with (68)Ga and (99m)Tc allowed precise molecular imaging of prostate cancer and PSMA-targeted small molecule labeled with 177Lu leads to the development of radionuclide-targeted therapy of prostate cancer. Despite its name, it has been shown that PSMA has been expressed in several malignancies which can be due to significant neovascularization. Present pictorial assay reports the nonspecific tracer uptake in some malignancies during (68)Ga-PSMA positron-emission tomography/computed tomography imaging and (99m)Tc-PSMA scintigraphy.
format Online
Article
Text
id pubmed-7745855
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-77458552020-12-21 An overview on prostate-specific membrane antigen uptake in malignancies other than prostate cancer: A pictorial essay Jafari, Esmail Ahmadzadehfar, Hojjat Dadgar, Habibollah Assadi, Majid World J Nucl Med Original Article Prostate-specific membrane antigen (PSMA) is a Type II transmembrane glycoprotein which is extremely overexpressed in prostate cancer epithelial cells. Recently, PSMA-targeted small molecule labeled with (68)Ga and (99m)Tc allowed precise molecular imaging of prostate cancer and PSMA-targeted small molecule labeled with 177Lu leads to the development of radionuclide-targeted therapy of prostate cancer. Despite its name, it has been shown that PSMA has been expressed in several malignancies which can be due to significant neovascularization. Present pictorial assay reports the nonspecific tracer uptake in some malignancies during (68)Ga-PSMA positron-emission tomography/computed tomography imaging and (99m)Tc-PSMA scintigraphy. Wolters Kluwer - Medknow 2020-07-22 /pmc/articles/PMC7745855/ /pubmed/33354182 http://dx.doi.org/10.4103/wjnm.WJNM_78_19 Text en Copyright: © 2020 World Journal of Nuclear Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Jafari, Esmail
Ahmadzadehfar, Hojjat
Dadgar, Habibollah
Assadi, Majid
An overview on prostate-specific membrane antigen uptake in malignancies other than prostate cancer: A pictorial essay
title An overview on prostate-specific membrane antigen uptake in malignancies other than prostate cancer: A pictorial essay
title_full An overview on prostate-specific membrane antigen uptake in malignancies other than prostate cancer: A pictorial essay
title_fullStr An overview on prostate-specific membrane antigen uptake in malignancies other than prostate cancer: A pictorial essay
title_full_unstemmed An overview on prostate-specific membrane antigen uptake in malignancies other than prostate cancer: A pictorial essay
title_short An overview on prostate-specific membrane antigen uptake in malignancies other than prostate cancer: A pictorial essay
title_sort overview on prostate-specific membrane antigen uptake in malignancies other than prostate cancer: a pictorial essay
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745855/
https://www.ncbi.nlm.nih.gov/pubmed/33354182
http://dx.doi.org/10.4103/wjnm.WJNM_78_19
work_keys_str_mv AT jafariesmail anoverviewonprostatespecificmembraneantigenuptakeinmalignanciesotherthanprostatecancerapictorialessay
AT ahmadzadehfarhojjat anoverviewonprostatespecificmembraneantigenuptakeinmalignanciesotherthanprostatecancerapictorialessay
AT dadgarhabibollah anoverviewonprostatespecificmembraneantigenuptakeinmalignanciesotherthanprostatecancerapictorialessay
AT assadimajid anoverviewonprostatespecificmembraneantigenuptakeinmalignanciesotherthanprostatecancerapictorialessay
AT jafariesmail overviewonprostatespecificmembraneantigenuptakeinmalignanciesotherthanprostatecancerapictorialessay
AT ahmadzadehfarhojjat overviewonprostatespecificmembraneantigenuptakeinmalignanciesotherthanprostatecancerapictorialessay
AT dadgarhabibollah overviewonprostatespecificmembraneantigenuptakeinmalignanciesotherthanprostatecancerapictorialessay
AT assadimajid overviewonprostatespecificmembraneantigenuptakeinmalignanciesotherthanprostatecancerapictorialessay

Ejemplares similares