Infection-induced 5′-half molecules of tRNA(HisGUG) activate Toll-like receptor 7

Toll-like receptors (TLRs) play a crucial role in the innate immune response. Although endosomal TLR7 recognizes single-stranded RNAs, their endogenous RNA ligands have not been fully explored. Here, we report 5′-tRNA half molecules as abundant activators of TLR7. Mycobacterial infection and accompa...

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Detalles Bibliográficos
Autores principales: Pawar, Kamlesh, Shigematsu, Megumi, Sharbati, Soroush, Kirino, Yohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745994/
https://www.ncbi.nlm.nih.gov/pubmed/33332353
http://dx.doi.org/10.1371/journal.pbio.3000982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745994/
https://www.ncbi.nlm.nih.gov/pubmed/33332353
http://dx.doi.org/10.1371/journal.pbio.3000982

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