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Infection-induced 5′-half molecules of tRNA(HisGUG) activate Toll-like receptor 7
Toll-like receptors (TLRs) play a crucial role in the innate immune response. Although endosomal TLR7 recognizes single-stranded RNAs, their endogenous RNA ligands have not been fully explored. Here, we report 5′-tRNA half molecules as abundant activators of TLR7. Mycobacterial infection and accompa...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745994/ https://www.ncbi.nlm.nih.gov/pubmed/33332353 http://dx.doi.org/10.1371/journal.pbio.3000982 |