Cargando…

Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study

BACKGROUND: The aetiology of Parkinson’s disease (PD) is still very controversial, with a peculiar lack of established risk factors or protective behavior. METHODS: We carried out a case–control study of 634 idiopathic PD patients admitted from 2011 to 2015 to two hospitals located in central Italy...

Descripción completa

Detalles Bibliográficos
Autores principales: Torti, Margherita, Fossati, Chiara, Casali, Miriam, De Pandis, Maria Francesca, Grassini, Paola, Radicati, Fabiana Giada, Stirpe, Paola, Vacca, Laura, Iavicoli, Ivo, Leso, Veruscka, Ceppi, Marcello, Bruzzone, Marco, Bonassi, Stefano, Stocchi, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746265/
https://www.ncbi.nlm.nih.gov/pubmed/33332388
http://dx.doi.org/10.1371/journal.pone.0243612
_version_ 1783624760498847744
author Torti, Margherita
Fossati, Chiara
Casali, Miriam
De Pandis, Maria Francesca
Grassini, Paola
Radicati, Fabiana Giada
Stirpe, Paola
Vacca, Laura
Iavicoli, Ivo
Leso, Veruscka
Ceppi, Marcello
Bruzzone, Marco
Bonassi, Stefano
Stocchi, Fabrizio
author_facet Torti, Margherita
Fossati, Chiara
Casali, Miriam
De Pandis, Maria Francesca
Grassini, Paola
Radicati, Fabiana Giada
Stirpe, Paola
Vacca, Laura
Iavicoli, Ivo
Leso, Veruscka
Ceppi, Marcello
Bruzzone, Marco
Bonassi, Stefano
Stocchi, Fabrizio
author_sort Torti, Margherita
collection PubMed
description BACKGROUND: The aetiology of Parkinson’s disease (PD) is still very controversial, with a peculiar lack of established risk factors or protective behavior. METHODS: We carried out a case–control study of 634 idiopathic PD patients admitted from 2011 to 2015 to two hospitals located in central Italy and 532 controls matched by hospital, gender and age (± 5 years). The study questionnaire included questions on host factors, family history, residence, occupation and lifestyle. Odds ratios (ORs) for PD and 95% confidence intervals (CIs) were estimated with logistic regression, adjusting for actual and potential confounders. RESULTS: A lower OR was observed in females (0.74; 95%CI:0.58–0.96), while older age classes showed a constantly increased risk for PD (p<0.005) starting from the class 65–69 years. Subjects who reported a first degree relative affected by PD showed a borderline increase which was more evident in those enrolled in the urban center of Rome (OR = 1.65; 95%CI: 1.09–2.50). Significant reduction of the risk was associated to current smoking (OR = 0.48; 95%CI: 0.24–0.54), and to vegetables consumption (p<0.03), while borderline increases were associated to meat and cold cut consumption. Occupational activities classified according to ISCO-08 categories did not show increased risk, while higher ORs’ were found for pilots and physicians. CONCLUSIONS: The results from this study confirmed the higher risk of PD in males and in elderly, and the inverse association with smoking habit. The possible etiological role of familial clustering, dietary habit, and some job tasks is suggested.
format Online
Article
Text
id pubmed-7746265
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-77462652020-12-31 Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study Torti, Margherita Fossati, Chiara Casali, Miriam De Pandis, Maria Francesca Grassini, Paola Radicati, Fabiana Giada Stirpe, Paola Vacca, Laura Iavicoli, Ivo Leso, Veruscka Ceppi, Marcello Bruzzone, Marco Bonassi, Stefano Stocchi, Fabrizio PLoS One Research Article BACKGROUND: The aetiology of Parkinson’s disease (PD) is still very controversial, with a peculiar lack of established risk factors or protective behavior. METHODS: We carried out a case–control study of 634 idiopathic PD patients admitted from 2011 to 2015 to two hospitals located in central Italy and 532 controls matched by hospital, gender and age (± 5 years). The study questionnaire included questions on host factors, family history, residence, occupation and lifestyle. Odds ratios (ORs) for PD and 95% confidence intervals (CIs) were estimated with logistic regression, adjusting for actual and potential confounders. RESULTS: A lower OR was observed in females (0.74; 95%CI:0.58–0.96), while older age classes showed a constantly increased risk for PD (p<0.005) starting from the class 65–69 years. Subjects who reported a first degree relative affected by PD showed a borderline increase which was more evident in those enrolled in the urban center of Rome (OR = 1.65; 95%CI: 1.09–2.50). Significant reduction of the risk was associated to current smoking (OR = 0.48; 95%CI: 0.24–0.54), and to vegetables consumption (p<0.03), while borderline increases were associated to meat and cold cut consumption. Occupational activities classified according to ISCO-08 categories did not show increased risk, while higher ORs’ were found for pilots and physicians. CONCLUSIONS: The results from this study confirmed the higher risk of PD in males and in elderly, and the inverse association with smoking habit. The possible etiological role of familial clustering, dietary habit, and some job tasks is suggested. Public Library of Science 2020-12-17 /pmc/articles/PMC7746265/ /pubmed/33332388 http://dx.doi.org/10.1371/journal.pone.0243612 Text en © 2020 Torti et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Torti, Margherita
Fossati, Chiara
Casali, Miriam
De Pandis, Maria Francesca
Grassini, Paola
Radicati, Fabiana Giada
Stirpe, Paola
Vacca, Laura
Iavicoli, Ivo
Leso, Veruscka
Ceppi, Marcello
Bruzzone, Marco
Bonassi, Stefano
Stocchi, Fabrizio
Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study
title Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study
title_full Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study
title_fullStr Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study
title_full_unstemmed Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study
title_short Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study
title_sort effect of family history, occupation and diet on the risk of parkinson disease: a case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746265/
https://www.ncbi.nlm.nih.gov/pubmed/33332388
http://dx.doi.org/10.1371/journal.pone.0243612
work_keys_str_mv AT tortimargherita effectoffamilyhistoryoccupationanddietontheriskofparkinsondiseaseacasecontrolstudy
AT fossatichiara effectoffamilyhistoryoccupationanddietontheriskofparkinsondiseaseacasecontrolstudy
AT casalimiriam effectoffamilyhistoryoccupationanddietontheriskofparkinsondiseaseacasecontrolstudy
AT depandismariafrancesca effectoffamilyhistoryoccupationanddietontheriskofparkinsondiseaseacasecontrolstudy
AT grassinipaola effectoffamilyhistoryoccupationanddietontheriskofparkinsondiseaseacasecontrolstudy
AT radicatifabianagiada effectoffamilyhistoryoccupationanddietontheriskofparkinsondiseaseacasecontrolstudy
AT stirpepaola effectoffamilyhistoryoccupationanddietontheriskofparkinsondiseaseacasecontrolstudy
AT vaccalaura effectoffamilyhistoryoccupationanddietontheriskofparkinsondiseaseacasecontrolstudy
AT iavicoliivo effectoffamilyhistoryoccupationanddietontheriskofparkinsondiseaseacasecontrolstudy
AT lesoveruscka effectoffamilyhistoryoccupationanddietontheriskofparkinsondiseaseacasecontrolstudy
AT ceppimarcello effectoffamilyhistoryoccupationanddietontheriskofparkinsondiseaseacasecontrolstudy
AT bruzzonemarco effectoffamilyhistoryoccupationanddietontheriskofparkinsondiseaseacasecontrolstudy
AT bonassistefano effectoffamilyhistoryoccupationanddietontheriskofparkinsondiseaseacasecontrolstudy
AT stocchifabrizio effectoffamilyhistoryoccupationanddietontheriskofparkinsondiseaseacasecontrolstudy