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Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study
BACKGROUND: The aetiology of Parkinson’s disease (PD) is still very controversial, with a peculiar lack of established risk factors or protective behavior. METHODS: We carried out a case–control study of 634 idiopathic PD patients admitted from 2011 to 2015 to two hospitals located in central Italy...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746265/ https://www.ncbi.nlm.nih.gov/pubmed/33332388 http://dx.doi.org/10.1371/journal.pone.0243612 |
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author | Torti, Margherita Fossati, Chiara Casali, Miriam De Pandis, Maria Francesca Grassini, Paola Radicati, Fabiana Giada Stirpe, Paola Vacca, Laura Iavicoli, Ivo Leso, Veruscka Ceppi, Marcello Bruzzone, Marco Bonassi, Stefano Stocchi, Fabrizio |
author_facet | Torti, Margherita Fossati, Chiara Casali, Miriam De Pandis, Maria Francesca Grassini, Paola Radicati, Fabiana Giada Stirpe, Paola Vacca, Laura Iavicoli, Ivo Leso, Veruscka Ceppi, Marcello Bruzzone, Marco Bonassi, Stefano Stocchi, Fabrizio |
author_sort | Torti, Margherita |
collection | PubMed |
description | BACKGROUND: The aetiology of Parkinson’s disease (PD) is still very controversial, with a peculiar lack of established risk factors or protective behavior. METHODS: We carried out a case–control study of 634 idiopathic PD patients admitted from 2011 to 2015 to two hospitals located in central Italy and 532 controls matched by hospital, gender and age (± 5 years). The study questionnaire included questions on host factors, family history, residence, occupation and lifestyle. Odds ratios (ORs) for PD and 95% confidence intervals (CIs) were estimated with logistic regression, adjusting for actual and potential confounders. RESULTS: A lower OR was observed in females (0.74; 95%CI:0.58–0.96), while older age classes showed a constantly increased risk for PD (p<0.005) starting from the class 65–69 years. Subjects who reported a first degree relative affected by PD showed a borderline increase which was more evident in those enrolled in the urban center of Rome (OR = 1.65; 95%CI: 1.09–2.50). Significant reduction of the risk was associated to current smoking (OR = 0.48; 95%CI: 0.24–0.54), and to vegetables consumption (p<0.03), while borderline increases were associated to meat and cold cut consumption. Occupational activities classified according to ISCO-08 categories did not show increased risk, while higher ORs’ were found for pilots and physicians. CONCLUSIONS: The results from this study confirmed the higher risk of PD in males and in elderly, and the inverse association with smoking habit. The possible etiological role of familial clustering, dietary habit, and some job tasks is suggested. |
format | Online Article Text |
id | pubmed-7746265 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-77462652020-12-31 Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study Torti, Margherita Fossati, Chiara Casali, Miriam De Pandis, Maria Francesca Grassini, Paola Radicati, Fabiana Giada Stirpe, Paola Vacca, Laura Iavicoli, Ivo Leso, Veruscka Ceppi, Marcello Bruzzone, Marco Bonassi, Stefano Stocchi, Fabrizio PLoS One Research Article BACKGROUND: The aetiology of Parkinson’s disease (PD) is still very controversial, with a peculiar lack of established risk factors or protective behavior. METHODS: We carried out a case–control study of 634 idiopathic PD patients admitted from 2011 to 2015 to two hospitals located in central Italy and 532 controls matched by hospital, gender and age (± 5 years). The study questionnaire included questions on host factors, family history, residence, occupation and lifestyle. Odds ratios (ORs) for PD and 95% confidence intervals (CIs) were estimated with logistic regression, adjusting for actual and potential confounders. RESULTS: A lower OR was observed in females (0.74; 95%CI:0.58–0.96), while older age classes showed a constantly increased risk for PD (p<0.005) starting from the class 65–69 years. Subjects who reported a first degree relative affected by PD showed a borderline increase which was more evident in those enrolled in the urban center of Rome (OR = 1.65; 95%CI: 1.09–2.50). Significant reduction of the risk was associated to current smoking (OR = 0.48; 95%CI: 0.24–0.54), and to vegetables consumption (p<0.03), while borderline increases were associated to meat and cold cut consumption. Occupational activities classified according to ISCO-08 categories did not show increased risk, while higher ORs’ were found for pilots and physicians. CONCLUSIONS: The results from this study confirmed the higher risk of PD in males and in elderly, and the inverse association with smoking habit. The possible etiological role of familial clustering, dietary habit, and some job tasks is suggested. Public Library of Science 2020-12-17 /pmc/articles/PMC7746265/ /pubmed/33332388 http://dx.doi.org/10.1371/journal.pone.0243612 Text en © 2020 Torti et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Torti, Margherita Fossati, Chiara Casali, Miriam De Pandis, Maria Francesca Grassini, Paola Radicati, Fabiana Giada Stirpe, Paola Vacca, Laura Iavicoli, Ivo Leso, Veruscka Ceppi, Marcello Bruzzone, Marco Bonassi, Stefano Stocchi, Fabrizio Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study |
title | Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study |
title_full | Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study |
title_fullStr | Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study |
title_full_unstemmed | Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study |
title_short | Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study |
title_sort | effect of family history, occupation and diet on the risk of parkinson disease: a case-control study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746265/ https://www.ncbi.nlm.nih.gov/pubmed/33332388 http://dx.doi.org/10.1371/journal.pone.0243612 |
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