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A multistationary loop model of ALS unveils critical molecular interactions involving mitochondria and glucose metabolism

Amyotrophic lateral sclerosis (ALS) is a poor-prognosis disease with puzzling pathogenesis and inconclusive treatments. We develop a mathematical model of ALS based on a system of interactive feedback loops, focusing on the mutant SOD1(G93A) mouse. Misfolded mutant SOD1 aggregates in motor neuron (M...

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Detalles Bibliográficos
Autores principales:	Burlando, Bruno, Milanese, Marco, Giordano, Giulia, Bonifacino, Tiziana, Ravera, Silvia, Blanchini, Franco, Bonanno, Giambattista
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746301/ https://www.ncbi.nlm.nih.gov/pubmed/33332476 http://dx.doi.org/10.1371/journal.pone.0244234

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