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Geniposide ameliorated sepsis-induced acute kidney injury by activating PPARγ
Acute kidney injury is one of the most common complications that occurs in septic shock. An effective therapeutic intervention is urgently needed. Geniposide has been reported to possess pleiotropic activities against different diseases. However, the effect of geniposide on sepsis-induced kidney inj...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746347/ https://www.ncbi.nlm.nih.gov/pubmed/33197894 http://dx.doi.org/10.18632/aging.103902 |
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author | Liu, Jinhong Zhao, Ning Shi, Guiling Wang, Hai |
author_facet | Liu, Jinhong Zhao, Ning Shi, Guiling Wang, Hai |
author_sort | Liu, Jinhong |
collection | PubMed |
description | Acute kidney injury is one of the most common complications that occurs in septic shock. An effective therapeutic intervention is urgently needed. Geniposide has been reported to possess pleiotropic activities against different diseases. However, the effect of geniposide on sepsis-induced kidney injury is unexplored. Our study aims to illustrate the mitigative effects of geniposide on sepsis-induced kidney injury and its relevant mechanisms. Sepsis was induced in mice undergoing cecal ligation and puncture (CLP) surgery. Mice were intraperitoneally injected with geniposide (10, 20 and 40 mg/kg) for treatment. The results showed that geniposide ameliorated kidney injury and dysfunction in CLP-induced septic mice, accompanied by reduction of inflammatory response and oxidative stress. We also found that geniposide significantly reduced vascular permeability and cellular apoptosis of the kidney, with increase of Bcl-2 and decrease of Bax and cleaved caspase-3. Moreover, PPARγ was found to be upregulated with the increasing concentration of geniposide. The protection of geniposide against inflammation and apoptosis was recovered by inhibition of PPARγ. Collectively, these results indicate that geniposide could significantly ameliorate acute kidney injury in CLP-induced septic mice and LPS-stimulated HK-2 cells by activating PPARγ. Geniposide might be a potential drug candidate for sepsis-induced kidney injury. |
format | Online Article Text |
id | pubmed-7746347 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-77463472021-01-04 Geniposide ameliorated sepsis-induced acute kidney injury by activating PPARγ Liu, Jinhong Zhao, Ning Shi, Guiling Wang, Hai Aging (Albany NY) Research Paper Acute kidney injury is one of the most common complications that occurs in septic shock. An effective therapeutic intervention is urgently needed. Geniposide has been reported to possess pleiotropic activities against different diseases. However, the effect of geniposide on sepsis-induced kidney injury is unexplored. Our study aims to illustrate the mitigative effects of geniposide on sepsis-induced kidney injury and its relevant mechanisms. Sepsis was induced in mice undergoing cecal ligation and puncture (CLP) surgery. Mice were intraperitoneally injected with geniposide (10, 20 and 40 mg/kg) for treatment. The results showed that geniposide ameliorated kidney injury and dysfunction in CLP-induced septic mice, accompanied by reduction of inflammatory response and oxidative stress. We also found that geniposide significantly reduced vascular permeability and cellular apoptosis of the kidney, with increase of Bcl-2 and decrease of Bax and cleaved caspase-3. Moreover, PPARγ was found to be upregulated with the increasing concentration of geniposide. The protection of geniposide against inflammation and apoptosis was recovered by inhibition of PPARγ. Collectively, these results indicate that geniposide could significantly ameliorate acute kidney injury in CLP-induced septic mice and LPS-stimulated HK-2 cells by activating PPARγ. Geniposide might be a potential drug candidate for sepsis-induced kidney injury. Impact Journals 2020-11-10 /pmc/articles/PMC7746347/ /pubmed/33197894 http://dx.doi.org/10.18632/aging.103902 Text en Copyright: © 2020 Liu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Liu, Jinhong Zhao, Ning Shi, Guiling Wang, Hai Geniposide ameliorated sepsis-induced acute kidney injury by activating PPARγ |
title | Geniposide ameliorated sepsis-induced acute kidney injury by activating PPARγ |
title_full | Geniposide ameliorated sepsis-induced acute kidney injury by activating PPARγ |
title_fullStr | Geniposide ameliorated sepsis-induced acute kidney injury by activating PPARγ |
title_full_unstemmed | Geniposide ameliorated sepsis-induced acute kidney injury by activating PPARγ |
title_short | Geniposide ameliorated sepsis-induced acute kidney injury by activating PPARγ |
title_sort | geniposide ameliorated sepsis-induced acute kidney injury by activating pparγ |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746347/ https://www.ncbi.nlm.nih.gov/pubmed/33197894 http://dx.doi.org/10.18632/aging.103902 |
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