Cargando…

The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer

The composition of immune infiltrates strongly affects the prognosis of patients with colorectal cancer (CRC). Interleukin (IL)-33 and regulatory T cells (Tregs) in the tumor microenvironment have been separately implicated in CRC; however their contribution to intestinal carcinogenesis is still con...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pastille, Eva, Wasmer, Marie-Hélène, Adamczyk, Alexandra, Vu, Vivian P., Mager, Lukas F., Phuong, Nhi Ngo Thi, Palmieri, Vittoria, Simillion, Cedric, Hansen, Wiebke, Kasper, Stefan, Schuler, Martin, Muggli, Beat, McCoy, Kathy D., Buer, Jan, Zlobec, Inti, Westendorf, Astrid M., Krebs, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746527/ https://www.ncbi.nlm.nih.gov/pubmed/31165767 http://dx.doi.org/10.1038/s41385-019-0176-y

Ejemplares similares

IL-33 Drives Expansion of Type 2 Innate Lymphoid Cells and Regulatory T Cells and Protects Mice From Severe, Acute Colitis
por: Ngo Thi Phuong, Nhi, et al.
Publicado: (2021)

Interleukin-33 signaling exacerbates experimental infectious colitis by enhancing gut permeability and inhibiting protective Th17 immunity
por: Palmieri, Vittoria, et al.
Publicado: (2021)

Inhibition of TLR4 Signaling Impedes Tumor Growth in Colitis-Associated Colon Cancer
por: Pastille, Eva, et al.
Publicado: (2021)

Depletion of Foxp3(+) regulatory T cells is accompanied by an increase in the relative abundance of Firmicutes in the murine gut microbiome
por: Kehrmann, Jan, et al.
Publicado: (2019)

TREM-1 promotes intestinal tumorigenesis
por: Saurer, Leslie, et al.
Publicado: (2017)

The IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice
por: Mertz, Kirsten D., et al.
Publicado: (2015)

The Role of IL-33-Dependent Inflammation in the Tumor Microenvironment
por: Wasmer, Marie-Hélène, et al.
Publicado: (2017)

Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer
por: Pastille, Eva, et al.
Publicado: (2017)

Distinct Kinetics in the Frequency of Peripheral CD4(+) T Cells in Patients with Ulcerative Colitis Experiencing a Flare during Treatment with Mesalazine or with a Herbal Preparation of Myrrh, Chamomile, and Coffee Charcoal
por: Langhorst, Jost, et al.
Publicado: (2014)

The ESRP1-GPR137 axis contributes to intestinal pathogenesis
por: Mager, Lukas Franz, et al.
Publicado: (2017)

Cytokine-Induced Modulation of Colorectal Cancer
por: Mager, Lukas F., et al.
Publicado: (2016)

Local Induction of Immunosuppressive CD8(+) T Cells in the Gut-Associated Lymphoid Tissues
por: Fleissner, Diana, et al.
Publicado: (2010)

Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: Tumor budding as oncotarget
por: Zlobec, Inti, et al.
Publicado: (2010)

The battle for prognosis at the invasive front of colorectal cancer
por: Lugli, Alessandro, et al.
Publicado: (2020)

Efficient nucleic acid delivery to murine regulatory T cells by gold nanoparticle conjugates
por: Gamrad, Lisa, et al.
Publicado: (2016)

Conventional CD11c(high) Dendritic Cells Are Important for T Cell Priming during the Initial Phase of Plasmodium yoelii Infection, but Are Dispensable at Later Time Points
por: Ueffing, Kristina, et al.
Publicado: (2017)

Loss of Raf-1 kinase inhibitor protein (RKIP) is strongly associated with high-grade tumor budding and correlates with an aggressive phenotype in pancreatic ductal adenocarcinoma (PDAC)
por: Karamitopoulou, Eva, et al.
Publicado: (2013)

Accumulation of FOXP3+T-cells in the tumor microenvironment is associated with an epithelial-mesenchymal-transition-type tumor budding phenotype and is an independent prognostic factor in surgically resected pancreatic ductal adenocarcinoma
por: Wartenberg, Martin, et al.
Publicado: (2015)

Tissue Microarray Technology for Molecular Applications: Investigation of Cross-Contamination between Tissue Samples Obtained from the Same Punching Device
por: Vassella, Erik, et al.
Publicado: (2015)

Tumour budding and its clinical implications in gastrointestinal cancers
por: Zlobec, Inti, et al.
Publicado: (2020)

Synthesis and structural characterization of Ca(12)Ga(14)O(33)
por: McCoy, Sabrina E. A., et al.
Publicado: (2020)

DC-Derived IL-10 Modulates Pro-inflammatory Cytokine Production and Promotes Induction of CD4(+)IL-10(+) Regulatory T Cells during Plasmodium yoelii Infection
por: Loevenich, Katharina, et al.
Publicado: (2017)

Role of Intra- and Peritumoral Budding in the Interdisciplinary Management of Rectal Cancer Patients
por: Zlobec, Inti, et al.
Publicado: (2012)

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
por: Zlobec, Inti, et al.
Publicado: (2014)

Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis
por: Meiners, Jana, et al.
Publicado: (2019)

Tumor Budding in Upper Gastrointestinal Carcinomas
por: Koelzer, Viktor H., et al.
Publicado: (2014)

Characterization of CDKN2A(p16) methylation and impact in colorectal cancer: systematic analysis using pyrosequencing
por: Bihl, Michel P, et al.
Publicado: (2012)

Update on the current opinion, status and future development of digital pathology in Switzerland in light of COVID-19
por: Koelzer, Viktor Hendrik, et al.
Publicado: (2022)

Breaking the co-operation between bystander T-cells and natural killer cells prevents the development of immunosuppression after traumatic skeletal muscle injury in mice
por: Wirsdörfer, Florian, et al.
Publicado: (2015)

The host response to the probiotic Escherichia coli strain Nissle 1917: Specific up-regulation of the proinflammatory chemokine MCP-1
por: Ukena, Sya N, et al.
Publicado: (2005)

T Cell-Specific Overexpression of Acid Sphingomyelinase Results in Elevated T Cell Activation and Reduced Parasitemia During Plasmodium yoelii Infection
por: Hose, Matthias, et al.
Publicado: (2019)

33 Ironman triathlons in 33 days–a case study
por: Knechtle, Beat, et al.
Publicado: (2014)

Targeting Antigens to Dec-205 on Dendritic Cells Induces Immune Protection in Experimental Colitis in Mice
por: Wadwa, Munisch, et al.
Publicado: (2016)

Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer
por: Eppenberger, Manuela, et al.
Publicado: (2010)

Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection
por: Knuschke, Torben, et al.
Publicado: (2016)

A combined spatial score of granzyme B and CD68 surpasses CD8 as an independent prognostic factor in TNM stage II colorectal cancer
por: Noti, Luca, et al.
Publicado: (2022)

Next-generation tissue microarray (ngTMA) increases the quality of biomarker studies: an example using CD3, CD8, and CD45RO in the tumor microenvironment of six different solid tumor types
por: Zlobec, Inti, et al.
Publicado: (2013)

Neuroendocrine Differentiation in Metastatic Conventional Prostate Cancer Is Significantly Increased in Lymph Node Metastases Compared to the Primary Tumors
por: Genitsch, Vera, et al.
Publicado: (2017)

Tumor Heterogeneity in Primary Colorectal Cancer and Corresponding Metastases. Does the Apple Fall Far From the Tree?
por: Blank, Annika, et al.
Publicado: (2018)

Editorial: Computational Pathology
por: Bozorgtabar, Behzad, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2oc11tgaimogkntt3t2ashs2th