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Blood Magnesium Level and Selected Oxidative Stress Indices in Lead-Exposed Workers

Occupational exposure to lead is one of the important hazards to human global population. Lead interferes with divalent cations, such as calcium, magnesium, and iron. Magnesium is the fourth most common mineral in the human body and a cofactor in more than 325 enzymes. There are many disorders assoc...

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Autores principales: Wyparło-Wszelaki, Magdalena, Wąsik, Marta, Machoń-Grecka, Anna, Kasperczyk, Aleksandra, Bellanti, Francesco, Kasperczyk, Sławomir, Dobrakowski, Michał
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746562/
https://www.ncbi.nlm.nih.gov/pubmed/32372126
http://dx.doi.org/10.1007/s12011-020-02168-x
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author Wyparło-Wszelaki, Magdalena
Wąsik, Marta
Machoń-Grecka, Anna
Kasperczyk, Aleksandra
Bellanti, Francesco
Kasperczyk, Sławomir
Dobrakowski, Michał
author_facet Wyparło-Wszelaki, Magdalena
Wąsik, Marta
Machoń-Grecka, Anna
Kasperczyk, Aleksandra
Bellanti, Francesco
Kasperczyk, Sławomir
Dobrakowski, Michał
author_sort Wyparło-Wszelaki, Magdalena
collection PubMed
description Occupational exposure to lead is one of the important hazards to human global population. Lead interferes with divalent cations, such as calcium, magnesium, and iron. Magnesium is the fourth most common mineral in the human body and a cofactor in more than 325 enzymes. There are many disorders associated with magnesium deficiency. It has been postulated that hypomagnesemia promotes oxidative stress. Study population included 232 male employees of lead-zinc works and was divided into two sub-groups based on the median of magnesium serum level: low magnesium level (L-Mg) group and high magnesium level (H-Mg) group. Magnesium level was significantly higher in the H-Mg group than in the L-Mg group due to the study design. The level of zinc protoporphyrin was significantly higher in the L-Mg group than in the H-Mg group by 13%, while the blood lead levels were similar in the examined groups. The serum level of MDA was significantly higher in the L-Mg group than in the H-Mg group by 12%, while the serum levels of thiol groups, TAC, and bilirubin were significantly lower in that group by 6%, 3%, and 27%, respectively. Similarly, the erythrocyte SOD activity was lower in the L-Mg group than in the H-Mg group by 5%. Low serum magnesium levels contribute to lead-induced oxidative stress, result in unfavorable modification of antioxidant system function, and promote lead-induced impairment of heme synthesis. Obtained results indicate that prevention of hypomagnesemia should be regarded as an important step in ensuring adequate prophylaxis of chronic lead poisoning.
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spelling pubmed-77465622020-12-21 Blood Magnesium Level and Selected Oxidative Stress Indices in Lead-Exposed Workers Wyparło-Wszelaki, Magdalena Wąsik, Marta Machoń-Grecka, Anna Kasperczyk, Aleksandra Bellanti, Francesco Kasperczyk, Sławomir Dobrakowski, Michał Biol Trace Elem Res Article Occupational exposure to lead is one of the important hazards to human global population. Lead interferes with divalent cations, such as calcium, magnesium, and iron. Magnesium is the fourth most common mineral in the human body and a cofactor in more than 325 enzymes. There are many disorders associated with magnesium deficiency. It has been postulated that hypomagnesemia promotes oxidative stress. Study population included 232 male employees of lead-zinc works and was divided into two sub-groups based on the median of magnesium serum level: low magnesium level (L-Mg) group and high magnesium level (H-Mg) group. Magnesium level was significantly higher in the H-Mg group than in the L-Mg group due to the study design. The level of zinc protoporphyrin was significantly higher in the L-Mg group than in the H-Mg group by 13%, while the blood lead levels were similar in the examined groups. The serum level of MDA was significantly higher in the L-Mg group than in the H-Mg group by 12%, while the serum levels of thiol groups, TAC, and bilirubin were significantly lower in that group by 6%, 3%, and 27%, respectively. Similarly, the erythrocyte SOD activity was lower in the L-Mg group than in the H-Mg group by 5%. Low serum magnesium levels contribute to lead-induced oxidative stress, result in unfavorable modification of antioxidant system function, and promote lead-induced impairment of heme synthesis. Obtained results indicate that prevention of hypomagnesemia should be regarded as an important step in ensuring adequate prophylaxis of chronic lead poisoning. Springer US 2020-05-06 2021 /pmc/articles/PMC7746562/ /pubmed/32372126 http://dx.doi.org/10.1007/s12011-020-02168-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wyparło-Wszelaki, Magdalena
Wąsik, Marta
Machoń-Grecka, Anna
Kasperczyk, Aleksandra
Bellanti, Francesco
Kasperczyk, Sławomir
Dobrakowski, Michał
Blood Magnesium Level and Selected Oxidative Stress Indices in Lead-Exposed Workers
title Blood Magnesium Level and Selected Oxidative Stress Indices in Lead-Exposed Workers
title_full Blood Magnesium Level and Selected Oxidative Stress Indices in Lead-Exposed Workers
title_fullStr Blood Magnesium Level and Selected Oxidative Stress Indices in Lead-Exposed Workers
title_full_unstemmed Blood Magnesium Level and Selected Oxidative Stress Indices in Lead-Exposed Workers
title_short Blood Magnesium Level and Selected Oxidative Stress Indices in Lead-Exposed Workers
title_sort blood magnesium level and selected oxidative stress indices in lead-exposed workers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746562/
https://www.ncbi.nlm.nih.gov/pubmed/32372126
http://dx.doi.org/10.1007/s12011-020-02168-x
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