Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency

Aberrant aggregation of RNA binding protein TDP-43 in neurons is a hallmark of frontotemporal lobar degeneration caused by progranulin haploinsufficiency(1,2). However, the mechanism leading to TDP-43 proteinopathy remains unclear. Here we use single-nucleus RNA-sequencing (snRNA-seq) to show that p...

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Detalles Bibliográficos
Autores principales: Zhang, Jiasheng, Velmeshev, Dmitry, Hashimoto, Kei, Huang, Yu-Hsin, Hofmann, Jeffrey W., Shi, Xiaoyu, Chen, Jiapei, Leidal, Andrew M., Dishart, Julian G., Cahill, Michelle K., Kelley, Kevin W., Liddelow, Shane A., Seeley, William W., Miller, Bruce L., Walther, Tobias C., Farese, Robert V., Taylor, J. Paul, Ullian, Erik M., Huang, Bo, Debnath, Jayanta, Wittmann, Torsten, Kriegstein, Arnold R., Huang, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746606/
https://www.ncbi.nlm.nih.gov/pubmed/32866962
http://dx.doi.org/10.1038/s41586-020-2709-7

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