Intravenous Nanoparticle Vaccination Generates Stem-Like TCF1(+) Neoantigen-Specific CD8(+) T Cells

Personalized cancer vaccines are a promising approach for inducing T cell immunity to tumor neoantigens. Using a self-assembling nanoparticle vaccine that links neoantigen peptides to a TLR7/8 agonist (SNP-7/8a), we show how the route and dose alter the magnitude and quality of neoantigen-specific C...

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Detalles Bibliográficos
Autores principales: Baharom, Faezzah, Ramirez-Valdez, Ramiro A, Tobin, Kennedy KS, Yamane, Hidehiro, Dutertre, Charles-Antoine, Khalilnezhad, Ahad, Reynoso, Glennys V, Coble, Vincent L, Lynn, Geoffrey M, Mulè, Matthew P, Martins, Andrew J, Finnigan, John P, Zhang, Xiao Meng, Hamerman, Jessica A, Bhardwaj, Nina, Tsang, John S, Hickman, Heather D, Ginhoux, Florent, Ishizuka, Andrew S, Seder, Robert A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746638/
https://www.ncbi.nlm.nih.gov/pubmed/33139915
http://dx.doi.org/10.1038/s41590-020-00810-3

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