Empagliflozin Decreases Lactate Generation in an NHE-1 Dependent Fashion and Increases α-Ketoglutarate Synthesis From Palmitate in Type II Diabetic Mouse Hearts

Aims/hypothesis: Changes in cardiac metabolism and ion homeostasis precede and drive cardiac remodeling and heart failure development. We previously demonstrated that sodium/glucose cotransporter 2 inhibitors (SGLT2i's) have direct cardiac effects on ion homeostasis, possibly through inhibition...

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Detalles Bibliográficos
Autores principales: Zhang, Hong, Uthman, Laween, Bakker, Diane, Sari, Sahinda, Chen, Sha, Hollmann, Markus W., Coronel, Ruben, Weber, Nina C., Houten, Sander M., van Weeghel, Michel, Zuurbier, Coert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746656/
https://www.ncbi.nlm.nih.gov/pubmed/33344518
http://dx.doi.org/10.3389/fcvm.2020.592233

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