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Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop

Multiple sclerosis is an autoimmune disease that affects the myelinated central nervous system (CNS) neurons and triggers physical and cognitive disabilities. Conventional therapy is based on disease-modifying drugs that control disease severity but can also be deleterious. Complementary medicines h...

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Autores principales: de Campos Fraga-Silva, Thais Fernanda, Mimura, Luiza Ayumi Nishiyama, de Oliveira, Larissa Ragozo Cardoso, dos Santos Toledo, Juliana Helena, Borim, Patrícia Aparecida, Zorzella-Pezavento, Sofia Fernanda Gonçalvez, Alonso, Diego Peres, Ribolla, Paulo Eduardo Martins, de Oliveira, Carlos Alberto Ferreira, da Fonseca, Denise Morais, Villablanca, Eduardo J., Sartori, Alexandrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746691/
https://www.ncbi.nlm.nih.gov/pubmed/33335128
http://dx.doi.org/10.1038/s41598-020-79102-7
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author de Campos Fraga-Silva, Thais Fernanda
Mimura, Luiza Ayumi Nishiyama
de Oliveira, Larissa Ragozo Cardoso
dos Santos Toledo, Juliana Helena
Borim, Patrícia Aparecida
Zorzella-Pezavento, Sofia Fernanda Gonçalvez
Alonso, Diego Peres
Ribolla, Paulo Eduardo Martins
de Oliveira, Carlos Alberto Ferreira
da Fonseca, Denise Morais
Villablanca, Eduardo J.
Sartori, Alexandrina
author_facet de Campos Fraga-Silva, Thais Fernanda
Mimura, Luiza Ayumi Nishiyama
de Oliveira, Larissa Ragozo Cardoso
dos Santos Toledo, Juliana Helena
Borim, Patrícia Aparecida
Zorzella-Pezavento, Sofia Fernanda Gonçalvez
Alonso, Diego Peres
Ribolla, Paulo Eduardo Martins
de Oliveira, Carlos Alberto Ferreira
da Fonseca, Denise Morais
Villablanca, Eduardo J.
Sartori, Alexandrina
author_sort de Campos Fraga-Silva, Thais Fernanda
collection PubMed
description Multiple sclerosis is an autoimmune disease that affects the myelinated central nervous system (CNS) neurons and triggers physical and cognitive disabilities. Conventional therapy is based on disease-modifying drugs that control disease severity but can also be deleterious. Complementary medicines have been adopted and evidence indicates that yeast supplements can improve symptoms mainly by modulating the immune response. In this investigation, we evaluated the therapeutic potential of Saccharomyces cerevisiae and its selenized derivative (Selemax) in experimental autoimmune encephalomyelitis (EAE). Female C57BL/6 mice submitted to EAE induction were orally supplemented with these yeasts by gavage from day 0 to day 14 after EAE induction. Both supplements determined significant reduction in clinical signs concomitantly with diminished Th1 immune response in CNS, increased proportion of Foxp3(+) lymphocytes in inguinal and mesenteric lymph nodes and increased microbiota diversity. However, Selemax was more effective clinically and immunologically; it reduced disease prevalence more sharply, increased the proportion of CD103(+) dendritic cells expressing high levels of PD-L1 in mesenteric lymph nodes and reduced the intestinal inflammatory process more strongly than S. cerevisiae. These results suggest a clear gut-brain axis modulation by selenized S. cerevisiae and suggest their inclusion in clinical trials.
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spelling pubmed-77466912020-12-18 Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop de Campos Fraga-Silva, Thais Fernanda Mimura, Luiza Ayumi Nishiyama de Oliveira, Larissa Ragozo Cardoso dos Santos Toledo, Juliana Helena Borim, Patrícia Aparecida Zorzella-Pezavento, Sofia Fernanda Gonçalvez Alonso, Diego Peres Ribolla, Paulo Eduardo Martins de Oliveira, Carlos Alberto Ferreira da Fonseca, Denise Morais Villablanca, Eduardo J. Sartori, Alexandrina Sci Rep Article Multiple sclerosis is an autoimmune disease that affects the myelinated central nervous system (CNS) neurons and triggers physical and cognitive disabilities. Conventional therapy is based on disease-modifying drugs that control disease severity but can also be deleterious. Complementary medicines have been adopted and evidence indicates that yeast supplements can improve symptoms mainly by modulating the immune response. In this investigation, we evaluated the therapeutic potential of Saccharomyces cerevisiae and its selenized derivative (Selemax) in experimental autoimmune encephalomyelitis (EAE). Female C57BL/6 mice submitted to EAE induction were orally supplemented with these yeasts by gavage from day 0 to day 14 after EAE induction. Both supplements determined significant reduction in clinical signs concomitantly with diminished Th1 immune response in CNS, increased proportion of Foxp3(+) lymphocytes in inguinal and mesenteric lymph nodes and increased microbiota diversity. However, Selemax was more effective clinically and immunologically; it reduced disease prevalence more sharply, increased the proportion of CD103(+) dendritic cells expressing high levels of PD-L1 in mesenteric lymph nodes and reduced the intestinal inflammatory process more strongly than S. cerevisiae. These results suggest a clear gut-brain axis modulation by selenized S. cerevisiae and suggest their inclusion in clinical trials. Nature Publishing Group UK 2020-12-17 /pmc/articles/PMC7746691/ /pubmed/33335128 http://dx.doi.org/10.1038/s41598-020-79102-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
de Campos Fraga-Silva, Thais Fernanda
Mimura, Luiza Ayumi Nishiyama
de Oliveira, Larissa Ragozo Cardoso
dos Santos Toledo, Juliana Helena
Borim, Patrícia Aparecida
Zorzella-Pezavento, Sofia Fernanda Gonçalvez
Alonso, Diego Peres
Ribolla, Paulo Eduardo Martins
de Oliveira, Carlos Alberto Ferreira
da Fonseca, Denise Morais
Villablanca, Eduardo J.
Sartori, Alexandrina
Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop
title Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop
title_full Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop
title_fullStr Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop
title_full_unstemmed Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop
title_short Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop
title_sort selenization of s. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746691/
https://www.ncbi.nlm.nih.gov/pubmed/33335128
http://dx.doi.org/10.1038/s41598-020-79102-7
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