Identification of hnRNP-A1 as a pharmacodynamic biomarker of type I PRMT inhibition in blood and tumor tissues

Arginine methylation has been recognized as a post-translational modification with pleiotropic effects that span from regulation of transcription to metabolic processes that contribute to aberrant cell proliferation and tumorigenesis. This has brought significant attention to the development of ther...

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Detalles Bibliográficos
Autores principales: Noto, Paul B., Sikorski, Timothy W., Zappacosta, Francesca, Wagner, Craig D., Montes de Oca, Rocio, Szapacs, Matthew E., Annan, Roland S., Liu, Yan, McHugh, Charles F., Mohammad, Helai P., Piccoli, Steven P., Creasy, Caretha L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746746/
https://www.ncbi.nlm.nih.gov/pubmed/33335114
http://dx.doi.org/10.1038/s41598-020-78800-6

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