CRISPR/Cas9-mediated knock-in of alligator cathelicidin gene in a non-coding region of channel catfish genome

CRISPR/Cas9-based gene knockout in animal cells, particularly in teleosts, has proven to be very efficient with regards to mutation rates, but the precise insertion of exogenous DNA or gene knock-in via the homology-directed repair (HDR) pathway has seldom been achieved outside of the model organism...

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Detalles Bibliográficos
Autores principales: Simora, Rhoda Mae C., Xing, De, Bangs, Max R., Wang, Wenwen, Ma, Xiaoli, Su, Baofeng, Khan, Mohd G. Q., Qin, Zhenkui, Lu, Cuiyu, Alston, Veronica, Hettiarachchi, Darshika, Johnson, Andrew, Li, Shangjia, Coogan, Michael, Gurbatow, Jeremy, Terhune, Jeffery S., Wang, Xu, Dunham, Rex A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746764/
https://www.ncbi.nlm.nih.gov/pubmed/33335280
http://dx.doi.org/10.1038/s41598-020-79409-5

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