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The Effects of Intranasal Oxytocin on Neural and Behavioral Responses to Social Touch in the Form of Massage

Manually-administered massage can potently increase endogenous oxytocin concentrations and neural activity in social cognition and reward regions and intranasal oxytocin can increase the pleasantness of social touch. In the present study, we investigated whether intranasal oxytocin modulates behavio...

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Autores principales: Chen, Yuanshu, Li, Qin, Zhang, Qianqian, Kou, Juan, Zhang, Yingying, Cui, Han, Wernicke, Jennifer, Montag, Christian, Becker, Benjamin, Kendrick, Keith M., Yao, Shuxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746800/
https://www.ncbi.nlm.nih.gov/pubmed/33343285
http://dx.doi.org/10.3389/fnins.2020.589878
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author Chen, Yuanshu
Li, Qin
Zhang, Qianqian
Kou, Juan
Zhang, Yingying
Cui, Han
Wernicke, Jennifer
Montag, Christian
Becker, Benjamin
Kendrick, Keith M.
Yao, Shuxia
author_facet Chen, Yuanshu
Li, Qin
Zhang, Qianqian
Kou, Juan
Zhang, Yingying
Cui, Han
Wernicke, Jennifer
Montag, Christian
Becker, Benjamin
Kendrick, Keith M.
Yao, Shuxia
author_sort Chen, Yuanshu
collection PubMed
description Manually-administered massage can potently increase endogenous oxytocin concentrations and neural activity in social cognition and reward regions and intranasal oxytocin can increase the pleasantness of social touch. In the present study, we investigated whether intranasal oxytocin modulates behavioral and neural responses to foot massage applied manually or by machine using a randomized placebo-controlled within-subject pharmaco-fMRI design. 46 male participants underwent blocks of massage of each type where they both received and imagined receiving the massage. Intranasal oxytocin significantly increased subjective pleasantness ratings of the manual but not the machine massage and neural responses in key regions involved in reward (orbitofrontal cortex, dorsal striatum and ventral tegmental area), social cognition (superior temporal sulcus and inferior parietal lobule), emotion and salience (amygdala and anterior cingulate and insula) and default mode networks (medial prefrontal cortex, parahippocampal gyrus, posterior cingulate, and precuneus) as well as a number of sensory and motor processing regions. Both neural and behavioral effects of oxytocin occurred independent of whether subjects thought the massage was applied by a male or female masseur. These findings support the importance of oxytocin for enhancing positive behavioral and neural responses to social touch in the form of manually administered massage and that a combination of intranasal oxytocin and massage may have therapeutic potential in autism. CLINICAL TRIALS REGISTRATION: The Effects of Oxytocin on Social Touch; registration ID: NCT03278860; URL: https://clinicaltrials.gov/ct2/show/NCT03278860.
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spelling pubmed-77468002020-12-19 The Effects of Intranasal Oxytocin on Neural and Behavioral Responses to Social Touch in the Form of Massage Chen, Yuanshu Li, Qin Zhang, Qianqian Kou, Juan Zhang, Yingying Cui, Han Wernicke, Jennifer Montag, Christian Becker, Benjamin Kendrick, Keith M. Yao, Shuxia Front Neurosci Neuroscience Manually-administered massage can potently increase endogenous oxytocin concentrations and neural activity in social cognition and reward regions and intranasal oxytocin can increase the pleasantness of social touch. In the present study, we investigated whether intranasal oxytocin modulates behavioral and neural responses to foot massage applied manually or by machine using a randomized placebo-controlled within-subject pharmaco-fMRI design. 46 male participants underwent blocks of massage of each type where they both received and imagined receiving the massage. Intranasal oxytocin significantly increased subjective pleasantness ratings of the manual but not the machine massage and neural responses in key regions involved in reward (orbitofrontal cortex, dorsal striatum and ventral tegmental area), social cognition (superior temporal sulcus and inferior parietal lobule), emotion and salience (amygdala and anterior cingulate and insula) and default mode networks (medial prefrontal cortex, parahippocampal gyrus, posterior cingulate, and precuneus) as well as a number of sensory and motor processing regions. Both neural and behavioral effects of oxytocin occurred independent of whether subjects thought the massage was applied by a male or female masseur. These findings support the importance of oxytocin for enhancing positive behavioral and neural responses to social touch in the form of manually administered massage and that a combination of intranasal oxytocin and massage may have therapeutic potential in autism. CLINICAL TRIALS REGISTRATION: The Effects of Oxytocin on Social Touch; registration ID: NCT03278860; URL: https://clinicaltrials.gov/ct2/show/NCT03278860. Frontiers Media S.A. 2020-12-04 /pmc/articles/PMC7746800/ /pubmed/33343285 http://dx.doi.org/10.3389/fnins.2020.589878 Text en Copyright © 2020 Chen, Li, Zhang, Kou, Zhang, Cui, Wernicke, Montag, Becker, Kendrick and Yao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Chen, Yuanshu
Li, Qin
Zhang, Qianqian
Kou, Juan
Zhang, Yingying
Cui, Han
Wernicke, Jennifer
Montag, Christian
Becker, Benjamin
Kendrick, Keith M.
Yao, Shuxia
The Effects of Intranasal Oxytocin on Neural and Behavioral Responses to Social Touch in the Form of Massage
title The Effects of Intranasal Oxytocin on Neural and Behavioral Responses to Social Touch in the Form of Massage
title_full The Effects of Intranasal Oxytocin on Neural and Behavioral Responses to Social Touch in the Form of Massage
title_fullStr The Effects of Intranasal Oxytocin on Neural and Behavioral Responses to Social Touch in the Form of Massage
title_full_unstemmed The Effects of Intranasal Oxytocin on Neural and Behavioral Responses to Social Touch in the Form of Massage
title_short The Effects of Intranasal Oxytocin on Neural and Behavioral Responses to Social Touch in the Form of Massage
title_sort effects of intranasal oxytocin on neural and behavioral responses to social touch in the form of massage
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746800/
https://www.ncbi.nlm.nih.gov/pubmed/33343285
http://dx.doi.org/10.3389/fnins.2020.589878
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