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miR-631 Inhibits Intrahepatic Metastasis of Hepatocellular Carcinoma by Targeting PTPRE

MicroRNAs (miRNAs) have been reported to play critical roles in the pathological development of hepatocellular carcinoma (HCC), one of the most common cancers in the world. Our study aims to explore the expression, function and mechanism of miR-631 in HCC. Our findings are that expression of miR-631...

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Autores principales: Chen, Bingqing, Liao, Zhibin, Qi, Yongqiang, Zhang, Hongwei, Su, Chen, Liang, Huifang, Zhang, Bixiang, Chen, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746836/
https://www.ncbi.nlm.nih.gov/pubmed/33344226
http://dx.doi.org/10.3389/fonc.2020.565266
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author Chen, Bingqing
Liao, Zhibin
Qi, Yongqiang
Zhang, Hongwei
Su, Chen
Liang, Huifang
Zhang, Bixiang
Chen, Xiaoping
author_facet Chen, Bingqing
Liao, Zhibin
Qi, Yongqiang
Zhang, Hongwei
Su, Chen
Liang, Huifang
Zhang, Bixiang
Chen, Xiaoping
author_sort Chen, Bingqing
collection PubMed
description MicroRNAs (miRNAs) have been reported to play critical roles in the pathological development of hepatocellular carcinoma (HCC), one of the most common cancers in the world. Our study aims to explore the expression, function and mechanism of miR-631 in HCC. Our findings are that expression of miR-631 is significantly down-regulated in HCC tissue compared with that in adjacent non-cancerous tissue, and low expression of miR-631 in HCC tissue is associated with cirrhosis, multiple tumors, incomplete tumor encapsulation, poor tumor differentiation, and high TNM stage. Our test results showed that miR-631 could inhibit migration, invasion, epithelial–mesenchymal transition (EMT) and intrahepatic metastasis of HCC. Receptor-type protein tyrosine phosphatase epsilon (PTPRE) as a downstream target of miR-631 could promote migration, invasion and EMT of HCC cells. Besides, the expression of PTPRE had a negative correlation with the expression of miR-631 both in vivo and in vitro, and increasing expression of PTPRE could reverse inhibitory effects of miR-631 in HCC cells. In sum, our study first demonstrated that miR-631 targeted PTPRE to inhibit intrahepatic metastasis in HCC. We gain insights from these findings into the mechanism of miRNAs regulation in HCC metastasis and further introduce a novel therapeutic target for HCC treatment.
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spelling pubmed-77468362020-12-19 miR-631 Inhibits Intrahepatic Metastasis of Hepatocellular Carcinoma by Targeting PTPRE Chen, Bingqing Liao, Zhibin Qi, Yongqiang Zhang, Hongwei Su, Chen Liang, Huifang Zhang, Bixiang Chen, Xiaoping Front Oncol Oncology MicroRNAs (miRNAs) have been reported to play critical roles in the pathological development of hepatocellular carcinoma (HCC), one of the most common cancers in the world. Our study aims to explore the expression, function and mechanism of miR-631 in HCC. Our findings are that expression of miR-631 is significantly down-regulated in HCC tissue compared with that in adjacent non-cancerous tissue, and low expression of miR-631 in HCC tissue is associated with cirrhosis, multiple tumors, incomplete tumor encapsulation, poor tumor differentiation, and high TNM stage. Our test results showed that miR-631 could inhibit migration, invasion, epithelial–mesenchymal transition (EMT) and intrahepatic metastasis of HCC. Receptor-type protein tyrosine phosphatase epsilon (PTPRE) as a downstream target of miR-631 could promote migration, invasion and EMT of HCC cells. Besides, the expression of PTPRE had a negative correlation with the expression of miR-631 both in vivo and in vitro, and increasing expression of PTPRE could reverse inhibitory effects of miR-631 in HCC cells. In sum, our study first demonstrated that miR-631 targeted PTPRE to inhibit intrahepatic metastasis in HCC. We gain insights from these findings into the mechanism of miRNAs regulation in HCC metastasis and further introduce a novel therapeutic target for HCC treatment. Frontiers Media S.A. 2020-12-04 /pmc/articles/PMC7746836/ /pubmed/33344226 http://dx.doi.org/10.3389/fonc.2020.565266 Text en Copyright © 2020 Chen, Liao, Qi, Zhang, Su, Liang, Zhang and Chen http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chen, Bingqing
Liao, Zhibin
Qi, Yongqiang
Zhang, Hongwei
Su, Chen
Liang, Huifang
Zhang, Bixiang
Chen, Xiaoping
miR-631 Inhibits Intrahepatic Metastasis of Hepatocellular Carcinoma by Targeting PTPRE
title miR-631 Inhibits Intrahepatic Metastasis of Hepatocellular Carcinoma by Targeting PTPRE
title_full miR-631 Inhibits Intrahepatic Metastasis of Hepatocellular Carcinoma by Targeting PTPRE
title_fullStr miR-631 Inhibits Intrahepatic Metastasis of Hepatocellular Carcinoma by Targeting PTPRE
title_full_unstemmed miR-631 Inhibits Intrahepatic Metastasis of Hepatocellular Carcinoma by Targeting PTPRE
title_short miR-631 Inhibits Intrahepatic Metastasis of Hepatocellular Carcinoma by Targeting PTPRE
title_sort mir-631 inhibits intrahepatic metastasis of hepatocellular carcinoma by targeting ptpre
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746836/
https://www.ncbi.nlm.nih.gov/pubmed/33344226
http://dx.doi.org/10.3389/fonc.2020.565266
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