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From Entry to Egress: Strategic Exploitation of the Cellular Processes by HIV-1
HIV-1 employs a rich arsenal of viral factors throughout its life cycle and co-opts intracellular trafficking pathways. This exquisitely coordinated process requires precise manipulation of the host microenvironment, most often within defined subcellular compartments. The virus capitalizes on the ho...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746852/ https://www.ncbi.nlm.nih.gov/pubmed/33343516 http://dx.doi.org/10.3389/fmicb.2020.559792 |
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author | Ramdas, Pavitra Sahu, Amit Kumar Mishra, Tarun Bhardwaj, Vipin Chande, Ajit |
author_facet | Ramdas, Pavitra Sahu, Amit Kumar Mishra, Tarun Bhardwaj, Vipin Chande, Ajit |
author_sort | Ramdas, Pavitra |
collection | PubMed |
description | HIV-1 employs a rich arsenal of viral factors throughout its life cycle and co-opts intracellular trafficking pathways. This exquisitely coordinated process requires precise manipulation of the host microenvironment, most often within defined subcellular compartments. The virus capitalizes on the host by modulating cell-surface proteins and cleverly exploiting nuclear import pathways for post entry events, among other key processes. Successful virus–cell interactions are indeed crucial in determining the extent of infection. By evolving defenses against host restriction factors, while simultaneously exploiting host dependency factors, the life cycle of HIV-1 presents a fascinating montage of an ongoing host–virus arms race. Herein, we provide an overview of how HIV-1 exploits native functions of the host cell and discuss recent findings that fundamentally change our understanding of the post-entry replication events. |
format | Online Article Text |
id | pubmed-7746852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77468522020-12-19 From Entry to Egress: Strategic Exploitation of the Cellular Processes by HIV-1 Ramdas, Pavitra Sahu, Amit Kumar Mishra, Tarun Bhardwaj, Vipin Chande, Ajit Front Microbiol Microbiology HIV-1 employs a rich arsenal of viral factors throughout its life cycle and co-opts intracellular trafficking pathways. This exquisitely coordinated process requires precise manipulation of the host microenvironment, most often within defined subcellular compartments. The virus capitalizes on the host by modulating cell-surface proteins and cleverly exploiting nuclear import pathways for post entry events, among other key processes. Successful virus–cell interactions are indeed crucial in determining the extent of infection. By evolving defenses against host restriction factors, while simultaneously exploiting host dependency factors, the life cycle of HIV-1 presents a fascinating montage of an ongoing host–virus arms race. Herein, we provide an overview of how HIV-1 exploits native functions of the host cell and discuss recent findings that fundamentally change our understanding of the post-entry replication events. Frontiers Media S.A. 2020-12-04 /pmc/articles/PMC7746852/ /pubmed/33343516 http://dx.doi.org/10.3389/fmicb.2020.559792 Text en Copyright © 2020 Ramdas, Sahu, Mishra, Bhardwaj and Chande. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Ramdas, Pavitra Sahu, Amit Kumar Mishra, Tarun Bhardwaj, Vipin Chande, Ajit From Entry to Egress: Strategic Exploitation of the Cellular Processes by HIV-1 |
title | From Entry to Egress: Strategic Exploitation of the Cellular Processes by HIV-1 |
title_full | From Entry to Egress: Strategic Exploitation of the Cellular Processes by HIV-1 |
title_fullStr | From Entry to Egress: Strategic Exploitation of the Cellular Processes by HIV-1 |
title_full_unstemmed | From Entry to Egress: Strategic Exploitation of the Cellular Processes by HIV-1 |
title_short | From Entry to Egress: Strategic Exploitation of the Cellular Processes by HIV-1 |
title_sort | from entry to egress: strategic exploitation of the cellular processes by hiv-1 |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746852/ https://www.ncbi.nlm.nih.gov/pubmed/33343516 http://dx.doi.org/10.3389/fmicb.2020.559792 |
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