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The Role of Intratumor Heterogeneity in the Response of Metastatic Non-Small Cell Lung Cancer to Immune Checkpoint Inhibitors

Immune checkpoint inhibitors (ICIs) represent one of the most promising therapeutic approaches in metastatic non-small cell lung cancer (M-NSCLC). Unfortunately, approximately 50–75% of patients do not respond to this treatment modality. Intratumor heterogeneity (ITH) at the genetic and phenotypic l...

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Detalles Bibliográficos
Autores principales: Nicoś, Marcin, Krawczyk, Paweł, Crosetto, Nicola, Milanowski, Janusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746867/
https://www.ncbi.nlm.nih.gov/pubmed/33344229
http://dx.doi.org/10.3389/fonc.2020.569202