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Morphine Antinociception Restored by Use of Methadone in the Morphine-Resistant Inflammatory Pain State

The antinociceptive effect of methadone in the morphine-resistant inflammatory pain state was described in the paw-withdrawal test using the complete Freund’s adjuvant (CFA)-induced mouse inflammatory pain model. After intraplantar (i.pl.) injection of CFA, thermal hyperalgesia was observed in the i...

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Detalles Bibliográficos
Autores principales:	Watanabe, Chizuko, Komiyama, Asami, Yoshizumi, Masaru, Sakurada, Shinobu, Mizoguchi, Hirokazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746881/ https://www.ncbi.nlm.nih.gov/pubmed/33343363 http://dx.doi.org/10.3389/fphar.2020.593647

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