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Identification of the Functional Binding Site for the Convulsant Tetramethylenedisulfotetramine in the Pore of the α(2)β(3)γ(2) GABA(A) Receptor

Tetramethylenedisulfotetramine (TETS) is a so-called “caged” convulsant that is responsible for thousands of accidental and malicious poisonings. Similar to the widely used GABA receptor type A (GABA(A)) antagonist picrotoxinin, TETS has been proposed to bind to the noncompetitive antagonist (NCA) s...

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Detalles Bibliográficos
Autores principales:	Pressly, Brandon, Lee, Ruth D., Barnych, Bogdan, Hammock, Bruce D., Wulff, Heike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746976/ https://www.ncbi.nlm.nih.gov/pubmed/33109687 http://dx.doi.org/10.1124/molpharm.120.000090

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