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Hearing Sensitivity, Cardiovascular Risk, and Neurocognitive Function: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

IMPORTANCE: Both cardiovascular disease risk and hearing impairment are associated with cognitive dysfunction. However, the combined influence of the 2 risk factors on cognition is not well characterized. OBJECTIVE: To examine associations between hearing impairment, cardiovascular disease risk, and...

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Autores principales: Stickel, Ariana M., Tarraf, Wassim, Bainbridge, Kathleen E., Viviano, Raymond P., Daviglus, Martha, Dhar, Sumitrajit, Gonzalez, Franklyn, Zeng, Donglin, González, Hector M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747041/
https://www.ncbi.nlm.nih.gov/pubmed/33331854
http://dx.doi.org/10.1001/jamaoto.2020.4835
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author Stickel, Ariana M.
Tarraf, Wassim
Bainbridge, Kathleen E.
Viviano, Raymond P.
Daviglus, Martha
Dhar, Sumitrajit
Gonzalez, Franklyn
Zeng, Donglin
González, Hector M.
author_facet Stickel, Ariana M.
Tarraf, Wassim
Bainbridge, Kathleen E.
Viviano, Raymond P.
Daviglus, Martha
Dhar, Sumitrajit
Gonzalez, Franklyn
Zeng, Donglin
González, Hector M.
author_sort Stickel, Ariana M.
collection PubMed
description IMPORTANCE: Both cardiovascular disease risk and hearing impairment are associated with cognitive dysfunction. However, the combined influence of the 2 risk factors on cognition is not well characterized. OBJECTIVE: To examine associations between hearing impairment, cardiovascular disease risk, and cognitive function. DESIGN, SETTING, AND PARTICIPANTS: This population-based, prospective cohort, multisite cross-sectional analysis of baseline data collected between 2008 and 2011 as part of the Hispanic Community Health Study/Study of Latinos included 9623 Hispanic or Latino adults aged 45 to 74 years in New York, Chicago, Miami, and San Diego. EXPOSURES: Hearing impairment of at least mild severity was defined as the pure tone average of 500, 1000, 2000, and 4000 Hz greater than 25 dB hearing level (dB HL) in the better ear. Our measure of cardiovascular disease risk was a latent class variable derived from body mass index, ankle-brachial index, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, fasting blood glucose, and the Framingham Cardiovascular Risk score. MAIN OUTCOMES AND MEASURES: Results on Brief-Spanish English Verbal Learning Test (episodic learning and memory), and Word Fluency (verbal fluency), and Digit Symbol Subtest (processing speed/executive functioning), and a cognitive composite of the mentioned tests (overall cognition). RESULTS: Participants (N = 9180) were 54.4% female and age 56.5 years on average. Hearing impairment was associated with poorer performance on all cognitive measures (global cognition: unstandardized β, −0.11; 95% CI, −0.16 to 0.07). Cardiovascular grouping (healthy, typical, high cardiovascular disease risk, and hyperglycemia) did not attenuate the associations between hearing impairment and cognition (global cognition: unstandardized β, −0.11; 95% CI, −0.15 to −0.06). However, cardiovascular grouping interacted with hearing impairment such that hyperglycemia in the context of hearing impairment exacerbated poor performance on learning and memory tasks (F(3) = 3.70 and F(3) = 2.92, respectively). CONCLUSIONS AND RELEVANCE: The findings of this cohort study suggest that hearing impairment increases the likelihood that individuals with excessively high glucose perform poorly on learning and memory tasks. Further research is needed to specify the mechanisms by which cardiovascular disease risk and hearing impairment are collectively associated with cognition.
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spelling pubmed-77470412020-12-21 Hearing Sensitivity, Cardiovascular Risk, and Neurocognitive Function: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Stickel, Ariana M. Tarraf, Wassim Bainbridge, Kathleen E. Viviano, Raymond P. Daviglus, Martha Dhar, Sumitrajit Gonzalez, Franklyn Zeng, Donglin González, Hector M. JAMA Otolaryngol Head Neck Surg Original Investigation IMPORTANCE: Both cardiovascular disease risk and hearing impairment are associated with cognitive dysfunction. However, the combined influence of the 2 risk factors on cognition is not well characterized. OBJECTIVE: To examine associations between hearing impairment, cardiovascular disease risk, and cognitive function. DESIGN, SETTING, AND PARTICIPANTS: This population-based, prospective cohort, multisite cross-sectional analysis of baseline data collected between 2008 and 2011 as part of the Hispanic Community Health Study/Study of Latinos included 9623 Hispanic or Latino adults aged 45 to 74 years in New York, Chicago, Miami, and San Diego. EXPOSURES: Hearing impairment of at least mild severity was defined as the pure tone average of 500, 1000, 2000, and 4000 Hz greater than 25 dB hearing level (dB HL) in the better ear. Our measure of cardiovascular disease risk was a latent class variable derived from body mass index, ankle-brachial index, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, fasting blood glucose, and the Framingham Cardiovascular Risk score. MAIN OUTCOMES AND MEASURES: Results on Brief-Spanish English Verbal Learning Test (episodic learning and memory), and Word Fluency (verbal fluency), and Digit Symbol Subtest (processing speed/executive functioning), and a cognitive composite of the mentioned tests (overall cognition). RESULTS: Participants (N = 9180) were 54.4% female and age 56.5 years on average. Hearing impairment was associated with poorer performance on all cognitive measures (global cognition: unstandardized β, −0.11; 95% CI, −0.16 to 0.07). Cardiovascular grouping (healthy, typical, high cardiovascular disease risk, and hyperglycemia) did not attenuate the associations between hearing impairment and cognition (global cognition: unstandardized β, −0.11; 95% CI, −0.15 to −0.06). However, cardiovascular grouping interacted with hearing impairment such that hyperglycemia in the context of hearing impairment exacerbated poor performance on learning and memory tasks (F(3) = 3.70 and F(3) = 2.92, respectively). CONCLUSIONS AND RELEVANCE: The findings of this cohort study suggest that hearing impairment increases the likelihood that individuals with excessively high glucose perform poorly on learning and memory tasks. Further research is needed to specify the mechanisms by which cardiovascular disease risk and hearing impairment are collectively associated with cognition. American Medical Association 2020-12-17 2021-04 /pmc/articles/PMC7747041/ /pubmed/33331854 http://dx.doi.org/10.1001/jamaoto.2020.4835 Text en Copyright 2020 Stickel AM et al. JAMA Otolaryngology–Head & Neck Surgery. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the CC-BY License.
spellingShingle Original Investigation
Stickel, Ariana M.
Tarraf, Wassim
Bainbridge, Kathleen E.
Viviano, Raymond P.
Daviglus, Martha
Dhar, Sumitrajit
Gonzalez, Franklyn
Zeng, Donglin
González, Hector M.
Hearing Sensitivity, Cardiovascular Risk, and Neurocognitive Function: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
title Hearing Sensitivity, Cardiovascular Risk, and Neurocognitive Function: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
title_full Hearing Sensitivity, Cardiovascular Risk, and Neurocognitive Function: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
title_fullStr Hearing Sensitivity, Cardiovascular Risk, and Neurocognitive Function: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
title_full_unstemmed Hearing Sensitivity, Cardiovascular Risk, and Neurocognitive Function: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
title_short Hearing Sensitivity, Cardiovascular Risk, and Neurocognitive Function: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
title_sort hearing sensitivity, cardiovascular risk, and neurocognitive function: the hispanic community health study/study of latinos (hchs/sol)
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747041/
https://www.ncbi.nlm.nih.gov/pubmed/33331854
http://dx.doi.org/10.1001/jamaoto.2020.4835
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