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Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant
Fibrillary and immunotactoid glomerulonephritis are infrequent causes of primary nephrotic range proteinuria and are poorly understood. Recent significant developments include the discovery of DNA JB9 antigen in fibrillary glomerulonephritis. Here, we present a case of a middle-aged woman who presen...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747065/ https://www.ncbi.nlm.nih.gov/pubmed/33363217 http://dx.doi.org/10.1159/000510871 |
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author | Vanga, Amaresh Magoon, Sandeep Kowalewska, Jolanta Mussarat, Saad |
author_facet | Vanga, Amaresh Magoon, Sandeep Kowalewska, Jolanta Mussarat, Saad |
author_sort | Vanga, Amaresh |
collection | PubMed |
description | Fibrillary and immunotactoid glomerulonephritis are infrequent causes of primary nephrotic range proteinuria and are poorly understood. Recent significant developments include the discovery of DNA JB9 antigen in fibrillary glomerulonephritis. Here, we present a case of a middle-aged woman who presented with nephrotic range proteinuria, hematuria, and normal renal function. Renal biopsy revealed fibrils that were randomly arranged on electron microscopy. They were of small size and congo red negative similar to the ones found in fibrillary glomerulonephritis, but were also DNA JB 9 negative, and had a hollow core like in immunotactoid glomerulopathy. Though we try to classify these conditions into either immunotactoid glomerulonephropathy (ITGN) or fibrillary glomerulonephritis (FGN), there are scenarios such as this case where it does not fit into either and is probably an overlap or intermediate variant of these two conditions. Pathological features of these glomerulonephrites are discussed together with their clinical implications, treatment choices, and diagnostic importance. |
format | Online Article Text |
id | pubmed-7747065 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-77470652020-12-24 Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant Vanga, Amaresh Magoon, Sandeep Kowalewska, Jolanta Mussarat, Saad Case Rep Nephrol Dial Case and Review Fibrillary and immunotactoid glomerulonephritis are infrequent causes of primary nephrotic range proteinuria and are poorly understood. Recent significant developments include the discovery of DNA JB9 antigen in fibrillary glomerulonephritis. Here, we present a case of a middle-aged woman who presented with nephrotic range proteinuria, hematuria, and normal renal function. Renal biopsy revealed fibrils that were randomly arranged on electron microscopy. They were of small size and congo red negative similar to the ones found in fibrillary glomerulonephritis, but were also DNA JB 9 negative, and had a hollow core like in immunotactoid glomerulopathy. Though we try to classify these conditions into either immunotactoid glomerulonephropathy (ITGN) or fibrillary glomerulonephritis (FGN), there are scenarios such as this case where it does not fit into either and is probably an overlap or intermediate variant of these two conditions. Pathological features of these glomerulonephrites are discussed together with their clinical implications, treatment choices, and diagnostic importance. S. Karger AG 2020-11-17 /pmc/articles/PMC7747065/ /pubmed/33363217 http://dx.doi.org/10.1159/000510871 Text en Copyright © 2020 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Case and Review Vanga, Amaresh Magoon, Sandeep Kowalewska, Jolanta Mussarat, Saad Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant |
title | Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant |
title_full | Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant |
title_fullStr | Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant |
title_full_unstemmed | Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant |
title_short | Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant |
title_sort | fibrilo-tactoid glomerulonephritis: a possible novel morphological variant |
topic | Case and Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747065/ https://www.ncbi.nlm.nih.gov/pubmed/33363217 http://dx.doi.org/10.1159/000510871 |
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