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Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant

Fibrillary and immunotactoid glomerulonephritis are infrequent causes of primary nephrotic range proteinuria and are poorly understood. Recent significant developments include the discovery of DNA JB9 antigen in fibrillary glomerulonephritis. Here, we present a case of a middle-aged woman who presen...

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Autores principales: Vanga, Amaresh, Magoon, Sandeep, Kowalewska, Jolanta, Mussarat, Saad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747065/
https://www.ncbi.nlm.nih.gov/pubmed/33363217
http://dx.doi.org/10.1159/000510871
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author Vanga, Amaresh
Magoon, Sandeep
Kowalewska, Jolanta
Mussarat, Saad
author_facet Vanga, Amaresh
Magoon, Sandeep
Kowalewska, Jolanta
Mussarat, Saad
author_sort Vanga, Amaresh
collection PubMed
description Fibrillary and immunotactoid glomerulonephritis are infrequent causes of primary nephrotic range proteinuria and are poorly understood. Recent significant developments include the discovery of DNA JB9 antigen in fibrillary glomerulonephritis. Here, we present a case of a middle-aged woman who presented with nephrotic range proteinuria, hematuria, and normal renal function. Renal biopsy revealed fibrils that were randomly arranged on electron microscopy. They were of small size and congo red negative similar to the ones found in fibrillary glomerulonephritis, but were also DNA JB 9 negative, and had a hollow core like in immunotactoid glomerulopathy. Though we try to classify these conditions into either immunotactoid glomerulonephropathy (ITGN) or fibrillary glomerulonephritis (FGN), there are scenarios such as this case where it does not fit into either and is probably an overlap or intermediate variant of these two conditions. Pathological features of these glomerulonephrites are discussed together with their clinical implications, treatment choices, and diagnostic importance.
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spelling pubmed-77470652020-12-24 Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant Vanga, Amaresh Magoon, Sandeep Kowalewska, Jolanta Mussarat, Saad Case Rep Nephrol Dial Case and Review Fibrillary and immunotactoid glomerulonephritis are infrequent causes of primary nephrotic range proteinuria and are poorly understood. Recent significant developments include the discovery of DNA JB9 antigen in fibrillary glomerulonephritis. Here, we present a case of a middle-aged woman who presented with nephrotic range proteinuria, hematuria, and normal renal function. Renal biopsy revealed fibrils that were randomly arranged on electron microscopy. They were of small size and congo red negative similar to the ones found in fibrillary glomerulonephritis, but were also DNA JB 9 negative, and had a hollow core like in immunotactoid glomerulopathy. Though we try to classify these conditions into either immunotactoid glomerulonephropathy (ITGN) or fibrillary glomerulonephritis (FGN), there are scenarios such as this case where it does not fit into either and is probably an overlap or intermediate variant of these two conditions. Pathological features of these glomerulonephrites are discussed together with their clinical implications, treatment choices, and diagnostic importance. S. Karger AG 2020-11-17 /pmc/articles/PMC7747065/ /pubmed/33363217 http://dx.doi.org/10.1159/000510871 Text en Copyright © 2020 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case and Review
Vanga, Amaresh
Magoon, Sandeep
Kowalewska, Jolanta
Mussarat, Saad
Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant
title Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant
title_full Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant
title_fullStr Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant
title_full_unstemmed Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant
title_short Fibrilo-Tactoid Glomerulonephritis: A Possible Novel Morphological Variant
title_sort fibrilo-tactoid glomerulonephritis: a possible novel morphological variant
topic Case and Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747065/
https://www.ncbi.nlm.nih.gov/pubmed/33363217
http://dx.doi.org/10.1159/000510871
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AT mussaratsaad fibrilotactoidglomerulonephritisapossiblenovelmorphologicalvariant