Cargando…
Statins, bone biology and revision arthroplasty: review of clinical and experimental evidence
Osteoarthritis is a painful, disabling condition which is increasing in prevalence as a result of an ageing population. With no recognized disease-limiting therapeutics, arthroplasty of the hip and knee is the most common and effective treatment for lower limb osteoarthritis, however lower limb arth...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747105/ https://www.ncbi.nlm.nih.gov/pubmed/33403020 http://dx.doi.org/10.1177/1759720X20966229 |
_version_ | 1783624924627206144 |
---|---|
author | Sorial, Antony K. Anjum, Sami A. Cook, Michael J. Board, Tim N. O’Neill, Terence W. |
author_facet | Sorial, Antony K. Anjum, Sami A. Cook, Michael J. Board, Tim N. O’Neill, Terence W. |
author_sort | Sorial, Antony K. |
collection | PubMed |
description | Osteoarthritis is a painful, disabling condition which is increasing in prevalence as a result of an ageing population. With no recognized disease-limiting therapeutics, arthroplasty of the hip and knee is the most common and effective treatment for lower limb osteoarthritis, however lower limb arthroplasty has a finite life-span and a proportion of patients will require revision arthroplasty. With increasing life expectancy and an increasing proportion of younger (<65 years) patients undergoing arthroplasty, the demand for revision arthroplasty after implant failure is also set to increase. Statins are cholesterol-modulating drugs widely used for cardiovascular risk reduction which have been noted to have pleiotropic effects including potentially influencing arthroplasty survival. In vitro studies have demonstrated pleiotropic effects in human bone cells, including enhancement of osteoblastogenesis following simvastatin exposure, and in vivo studies have demonstrated that intraperitoneal simvastatin can increase peri-implant bone growth in rats following titanium tibial implant insertion. There is evidence that statins may also influence osseointegration, enhancing bone growth at the bone–implant interface, subsequently improving the functional survival of implants. Data from the Danish Hip Arthroplasty Registry and the Clinical Practice Research Datalink in the UK suggest a reduction in the risk of lower limb revision arthroplasty in statin ever-users versus never-users, and a time-dependent effect of statins in reducing the risk of revision. In this article we review the clinical and experimental evidence linking statins and risk of revision arthroplasty. |
format | Online Article Text |
id | pubmed-7747105 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-77471052021-01-04 Statins, bone biology and revision arthroplasty: review of clinical and experimental evidence Sorial, Antony K. Anjum, Sami A. Cook, Michael J. Board, Tim N. O’Neill, Terence W. Ther Adv Musculoskelet Dis Review Osteoarthritis is a painful, disabling condition which is increasing in prevalence as a result of an ageing population. With no recognized disease-limiting therapeutics, arthroplasty of the hip and knee is the most common and effective treatment for lower limb osteoarthritis, however lower limb arthroplasty has a finite life-span and a proportion of patients will require revision arthroplasty. With increasing life expectancy and an increasing proportion of younger (<65 years) patients undergoing arthroplasty, the demand for revision arthroplasty after implant failure is also set to increase. Statins are cholesterol-modulating drugs widely used for cardiovascular risk reduction which have been noted to have pleiotropic effects including potentially influencing arthroplasty survival. In vitro studies have demonstrated pleiotropic effects in human bone cells, including enhancement of osteoblastogenesis following simvastatin exposure, and in vivo studies have demonstrated that intraperitoneal simvastatin can increase peri-implant bone growth in rats following titanium tibial implant insertion. There is evidence that statins may also influence osseointegration, enhancing bone growth at the bone–implant interface, subsequently improving the functional survival of implants. Data from the Danish Hip Arthroplasty Registry and the Clinical Practice Research Datalink in the UK suggest a reduction in the risk of lower limb revision arthroplasty in statin ever-users versus never-users, and a time-dependent effect of statins in reducing the risk of revision. In this article we review the clinical and experimental evidence linking statins and risk of revision arthroplasty. SAGE Publications 2020-12-16 /pmc/articles/PMC7747105/ /pubmed/33403020 http://dx.doi.org/10.1177/1759720X20966229 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Sorial, Antony K. Anjum, Sami A. Cook, Michael J. Board, Tim N. O’Neill, Terence W. Statins, bone biology and revision arthroplasty: review of clinical and experimental evidence |
title | Statins, bone biology and revision arthroplasty: review of clinical
and experimental evidence |
title_full | Statins, bone biology and revision arthroplasty: review of clinical
and experimental evidence |
title_fullStr | Statins, bone biology and revision arthroplasty: review of clinical
and experimental evidence |
title_full_unstemmed | Statins, bone biology and revision arthroplasty: review of clinical
and experimental evidence |
title_short | Statins, bone biology and revision arthroplasty: review of clinical
and experimental evidence |
title_sort | statins, bone biology and revision arthroplasty: review of clinical
and experimental evidence |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747105/ https://www.ncbi.nlm.nih.gov/pubmed/33403020 http://dx.doi.org/10.1177/1759720X20966229 |
work_keys_str_mv | AT sorialantonyk statinsbonebiologyandrevisionarthroplastyreviewofclinicalandexperimentalevidence AT anjumsamia statinsbonebiologyandrevisionarthroplastyreviewofclinicalandexperimentalevidence AT cookmichaelj statinsbonebiologyandrevisionarthroplastyreviewofclinicalandexperimentalevidence AT boardtimn statinsbonebiologyandrevisionarthroplastyreviewofclinicalandexperimentalevidence AT oneillterencew statinsbonebiologyandrevisionarthroplastyreviewofclinicalandexperimentalevidence |