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Enhancing Combined Immunotherapy and Radiotherapy through Nanomedicine

[Image: see text] Radiotherapy and immunotherapy are two key treatments for cancer. There is growing evidence that they are also synergistic, and combination treatments are being studied extensively in the clinical setting. In addition, there is emerging evidence that nanotechnology-enabled therapeu...

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Detalles Bibliográficos
Autores principales: Hagan, C. Tilden, Mi, Yu, Knape, Nicole M., Wang, Andrew Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747221/
https://www.ncbi.nlm.nih.gov/pubmed/33251789
http://dx.doi.org/10.1021/acs.bioconjchem.0c00520
Descripción
Sumario:[Image: see text] Radiotherapy and immunotherapy are two key treatments for cancer. There is growing evidence that they are also synergistic, and combination treatments are being studied extensively in the clinical setting. In addition, there is emerging evidence that nanotechnology-enabled therapeutics can potentiate both radiotherapy and immunotherapy, in turn improving both treatments. This is an exciting new area of interdisciplinary science and has significant potential for major clinical impact. Some of the approaches in this area have already reached the clinical stage. In this review, we will discuss recent advances in the interface between radiotherapy, immunotherapy, and nanomedicine. We plan to review the many approaches to combine these three fields for cancer treatment.