Letter to the Editor: “Glucocorticoid Resistance in Premature Adrenarche and PCOS: From Childhood to Adulthood”

The conclusion of Panayiotopoulos et al. that glucocorticoid resistance accounted for 57% to 67% of their premature adrenarche and polycystic ovary syndrome cases cannot be accepted from the data presented. This is because proper validation of their method for determining glucocorticoid sensitivity...

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Detalles Bibliográficos
Autor principal: Rosenfield, Robert L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747361/
https://www.ncbi.nlm.nih.gov/pubmed/33367193
http://dx.doi.org/10.1210/jendso/bvaa163
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author Rosenfield, Robert L
author_facet Rosenfield, Robert L
author_sort Rosenfield, Robert L
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description The conclusion of Panayiotopoulos et al. that glucocorticoid resistance accounted for 57% to 67% of their premature adrenarche and polycystic ovary syndrome cases cannot be accepted from the data presented. This is because proper validation of their method for determining glucocorticoid sensitivity is not presented. Furthermore, the method seems insensitive to physiologic glucocorticoid concentrations.
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spelling pubmed-77473612020-12-22 Letter to the Editor: “Glucocorticoid Resistance in Premature Adrenarche and PCOS: From Childhood to Adulthood” Rosenfield, Robert L J Endocr Soc Letter to the Editor The conclusion of Panayiotopoulos et al. that glucocorticoid resistance accounted for 57% to 67% of their premature adrenarche and polycystic ovary syndrome cases cannot be accepted from the data presented. This is because proper validation of their method for determining glucocorticoid sensitivity is not presented. Furthermore, the method seems insensitive to physiologic glucocorticoid concentrations. Oxford University Press 2020-11-07 /pmc/articles/PMC7747361/ /pubmed/33367193 http://dx.doi.org/10.1210/jendso/bvaa163 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Letter to the Editor
Rosenfield, Robert L
Letter to the Editor: “Glucocorticoid Resistance in Premature Adrenarche and PCOS: From Childhood to Adulthood”
title Letter to the Editor: “Glucocorticoid Resistance in Premature Adrenarche and PCOS: From Childhood to Adulthood”
title_full Letter to the Editor: “Glucocorticoid Resistance in Premature Adrenarche and PCOS: From Childhood to Adulthood”
title_fullStr Letter to the Editor: “Glucocorticoid Resistance in Premature Adrenarche and PCOS: From Childhood to Adulthood”
title_full_unstemmed Letter to the Editor: “Glucocorticoid Resistance in Premature Adrenarche and PCOS: From Childhood to Adulthood”
title_short Letter to the Editor: “Glucocorticoid Resistance in Premature Adrenarche and PCOS: From Childhood to Adulthood”
title_sort letter to the editor: “glucocorticoid resistance in premature adrenarche and pcos: from childhood to adulthood”
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747361/
https://www.ncbi.nlm.nih.gov/pubmed/33367193
http://dx.doi.org/10.1210/jendso/bvaa163
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