A Coronavirus Disease 2019 (COVID-19) Mystery: Persistent Fevers and Leukocytosis in a Patient With Severe COVID-19

Short-course glucocorticosteroids are being used and tocilizumab (TCZ) had been used to treat patients with severe coronavirus disease 2019 (COVID-19) disease. These agents, when administered individually, have been associated with tuberculosis (TB) during chronic use. We report a case of TB in a 44...

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Autores principales: Sasson, Arielle, Aijaz, Amna, Chernyavsky, Svetlana, Salomon, Nadim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Novel ID Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747365/
https://www.ncbi.nlm.nih.gov/pubmed/33365357
http://dx.doi.org/10.1093/ofid/ofaa558
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author Sasson, Arielle
Aijaz, Amna
Chernyavsky, Svetlana
Salomon, Nadim
author_facet Sasson, Arielle
Aijaz, Amna
Chernyavsky, Svetlana
Salomon, Nadim
author_sort Sasson, Arielle
collection PubMed
description Short-course glucocorticosteroids are being used and tocilizumab (TCZ) had been used to treat patients with severe coronavirus disease 2019 (COVID-19) disease. These agents, when administered individually, have been associated with tuberculosis (TB) during chronic use. We report a case of TB in a 44-year-old male with diabetes and severe COVID-19 who received high-dose short-course glucocorticosteroids and a single dose of TCZ. The clinical presentation was atypical with unresolving fevers and leukocytosis, progressive lower lobe cavities, and hilar adenopathy. Delayed diagnosis led to prolonged hospitalization and extensive antibiotic use.
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spelling pubmed-77473652020-12-22 A Coronavirus Disease 2019 (COVID-19) Mystery: Persistent Fevers and Leukocytosis in a Patient With Severe COVID-19 Sasson, Arielle Aijaz, Amna Chernyavsky, Svetlana Salomon, Nadim Open Forum Infect Dis Novel ID Cases Short-course glucocorticosteroids are being used and tocilizumab (TCZ) had been used to treat patients with severe coronavirus disease 2019 (COVID-19) disease. These agents, when administered individually, have been associated with tuberculosis (TB) during chronic use. We report a case of TB in a 44-year-old male with diabetes and severe COVID-19 who received high-dose short-course glucocorticosteroids and a single dose of TCZ. The clinical presentation was atypical with unresolving fevers and leukocytosis, progressive lower lobe cavities, and hilar adenopathy. Delayed diagnosis led to prolonged hospitalization and extensive antibiotic use. Oxford University Press 2020-12-18 /pmc/articles/PMC7747365/ /pubmed/33365357 http://dx.doi.org/10.1093/ofid/ofaa558 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Novel ID Cases
Sasson, Arielle
Aijaz, Amna
Chernyavsky, Svetlana
Salomon, Nadim
A Coronavirus Disease 2019 (COVID-19) Mystery: Persistent Fevers and Leukocytosis in a Patient With Severe COVID-19
title A Coronavirus Disease 2019 (COVID-19) Mystery: Persistent Fevers and Leukocytosis in a Patient With Severe COVID-19
title_full A Coronavirus Disease 2019 (COVID-19) Mystery: Persistent Fevers and Leukocytosis in a Patient With Severe COVID-19
title_fullStr A Coronavirus Disease 2019 (COVID-19) Mystery: Persistent Fevers and Leukocytosis in a Patient With Severe COVID-19
title_full_unstemmed A Coronavirus Disease 2019 (COVID-19) Mystery: Persistent Fevers and Leukocytosis in a Patient With Severe COVID-19
title_short A Coronavirus Disease 2019 (COVID-19) Mystery: Persistent Fevers and Leukocytosis in a Patient With Severe COVID-19
title_sort coronavirus disease 2019 (covid-19) mystery: persistent fevers and leukocytosis in a patient with severe covid-19
topic Novel ID Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747365/
https://www.ncbi.nlm.nih.gov/pubmed/33365357
http://dx.doi.org/10.1093/ofid/ofaa558
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