Patient characteristics associated with COVID-19 positivity and fatality in Nigeria: retrospective cohort study

OBJECTIVE: Despite the increasing disease burden, there is a dearth of context-specific evidence on the risk factors for COVID-19 positivity and subsequent death in Nigeria. Thus, the study objective was to identify context-specific factors associated with testing positive for COVID-19 and fatality...

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Detalles Bibliográficos
Autores principales: Elimian, Kelly Osezele, Ochu, Chinwe Lucia, Ebhodaghe, Blessing, Myles, Puja, Crawford, Emily E, Igumbor, Ehimario, Ukponu, Winifred, Olayinka, Adobola, Aruna, Olusola, Dan-Nwafor, Chioma, Olawepo, Olatayo Ayodeji, Ogunbode, Oladipo, Atteh, Rhoda, Nwachukwu, William, Venkatesan, Sudhir, Obagha, Chijioke, Ngishe, Samuel, Suleiman, Kabir, Usman, Muhammad, Yusuff, Hakeem Abiola, Nwadiuto, Ifeoma, Mohammed, Abbas Aliyu, Usman, Rabi, Mba, Nwando, Aderinola, Olaolu, Ilori, Elsie, Oladejo, John, Abubakar, Ibrahim, Ihekweazu, Chikwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747485/
https://www.ncbi.nlm.nih.gov/pubmed/33334842
http://dx.doi.org/10.1136/bmjopen-2020-044079
Descripción
Sumario:OBJECTIVE: Despite the increasing disease burden, there is a dearth of context-specific evidence on the risk factors for COVID-19 positivity and subsequent death in Nigeria. Thus, the study objective was to identify context-specific factors associated with testing positive for COVID-19 and fatality in Nigeria. DESIGN: Retrospective cohort study. SETTING: COVID-19 surveillance and laboratory centres in 36 states and the Federal Capital Territory reporting data to the Nigeria Centre for Disease Control. PARTICIPANTS: Individuals who were investigated for SARS-CoV-2 using real-time PCR testing during the study period 27 February–8 June 2020. METHODS: COVID-19 positivity and subsequent mortality. Multivariable logistic regression analyses were performed to identify factors independently associated with both outcome variables, and findings are presented as adjusted ORs (aORs) and 95% CIs. RESULTS: A total of 36 496 patients were tested for COVID-19, with 10 517 confirmed cases. Of 3215 confirmed cases with available clinical outcomes, 295 died. Factors independently associated with COVID-19 positivity were older age (p value for trend<0.0001), male sex (aOR 1.11, 95% CI 1.04 to 1.18) and the following presenting symptoms: cough (aOR 1.23, 95% CI 1.13 to 1.32), fever (aOR 1.45, 95% CI 1.45 to 1.71), loss of smell (aOR 7.78, 95% CI 5.19 to 11.66) and loss of taste (aOR 2.50, 95% CI 1.60 to 3.90). An increased risk of mortality following COVID-19 was observed in those aged ≥51 years, patients in farming occupation (aOR 7.56, 95% CI 1.70 to 33.53) and those presenting with cough (aOR 2.06, 95% CI 1.41 to 3.01), breathing difficulties (aOR 5.68, 95% CI 3.77 to 8.58) and vomiting (aOR 2.54, 95% CI 1.33 to 4.84). CONCLUSION: The significant risk factors associated with COVID-19 positivity and subsequent mortality in the Nigerian population are similar to those reported in studies from other countries and should guide clinical decisions for COVID-19 testing and specialist care referrals.

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