Selective enhancement of fear learning and resistance to extinction in a mouse model of acute early life trauma

Early life stress (ELS) experiences can cause changes in cognitive and affective functioning. This study examined the persistent effects of a single traumatic event in infancy on several adult behavioral outcomes in male and female C57BL/6J mice. Mice received 15 footshocks in infancy and were teste...

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Detalles Bibliográficos
Autores principales: Sneddon, Elizabeth A., Riddle, Collin A., Schuh, Kristen M., Quinn, Jennifer J., Radke, Anna K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747648/
https://www.ncbi.nlm.nih.gov/pubmed/33323497
http://dx.doi.org/10.1101/lm.052373.120
Descripción
Sumario:Early life stress (ELS) experiences can cause changes in cognitive and affective functioning. This study examined the persistent effects of a single traumatic event in infancy on several adult behavioral outcomes in male and female C57BL/6J mice. Mice received 15 footshocks in infancy and were tested for stress-enhanced fear learning, extinction learning, discrimination and reversal learning, and novel object recognition. Infant trauma potentiated fear learning in adulthood and produced resistance to extinction but did not influence other behaviors, suggesting restricted effects of infant trauma on behaviors reliant on cortico-amygdala circuitry.

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