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Reliable induction of sleep spindles with intracranial electrical pulse stimulation

Neocortical sleep spindles have been shown to occur more frequently following a memory task, suggesting that a method to increase spindle activity could improve memory processing. Stimulation of the neocortex can elicit a slow oscillation (SO) and a spindle, but the feasibility of this method to boo...

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Detalles Bibliográficos
Autores principales: Eckert, Michael J., Iyer, Kartik, Euston, David R., Tatsuno, Masami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747649/
https://www.ncbi.nlm.nih.gov/pubmed/33323496
http://dx.doi.org/10.1101/lm.052464.120
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author Eckert, Michael J.
Iyer, Kartik
Euston, David R.
Tatsuno, Masami
author_facet Eckert, Michael J.
Iyer, Kartik
Euston, David R.
Tatsuno, Masami
author_sort Eckert, Michael J.
collection PubMed
description Neocortical sleep spindles have been shown to occur more frequently following a memory task, suggesting that a method to increase spindle activity could improve memory processing. Stimulation of the neocortex can elicit a slow oscillation (SO) and a spindle, but the feasibility of this method to boost SO and spindles over time has not been tested. In rats with implanted neocortical electrodes, stimulation during slow wave sleep significantly increased SO and spindle rates compared to control rest periods before and after the stimulation session. Coordination between hippocampal sharp-wave ripples and spindles also increased. These effects were reproducible across five consecutive days of testing, demonstrating the viability of this method to increase SO and spindles.
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spelling pubmed-77476492022-01-01 Reliable induction of sleep spindles with intracranial electrical pulse stimulation Eckert, Michael J. Iyer, Kartik Euston, David R. Tatsuno, Masami Learn Mem Brief Communication Neocortical sleep spindles have been shown to occur more frequently following a memory task, suggesting that a method to increase spindle activity could improve memory processing. Stimulation of the neocortex can elicit a slow oscillation (SO) and a spindle, but the feasibility of this method to boost SO and spindles over time has not been tested. In rats with implanted neocortical electrodes, stimulation during slow wave sleep significantly increased SO and spindle rates compared to control rest periods before and after the stimulation session. Coordination between hippocampal sharp-wave ripples and spindles also increased. These effects were reproducible across five consecutive days of testing, demonstrating the viability of this method to increase SO and spindles. Cold Spring Harbor Laboratory Press 2021-01 /pmc/articles/PMC7747649/ /pubmed/33323496 http://dx.doi.org/10.1101/lm.052464.120 Text en © 2021 Eckert et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Brief Communication
Eckert, Michael J.
Iyer, Kartik
Euston, David R.
Tatsuno, Masami
Reliable induction of sleep spindles with intracranial electrical pulse stimulation
title Reliable induction of sleep spindles with intracranial electrical pulse stimulation
title_full Reliable induction of sleep spindles with intracranial electrical pulse stimulation
title_fullStr Reliable induction of sleep spindles with intracranial electrical pulse stimulation
title_full_unstemmed Reliable induction of sleep spindles with intracranial electrical pulse stimulation
title_short Reliable induction of sleep spindles with intracranial electrical pulse stimulation
title_sort reliable induction of sleep spindles with intracranial electrical pulse stimulation
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747649/
https://www.ncbi.nlm.nih.gov/pubmed/33323496
http://dx.doi.org/10.1101/lm.052464.120
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