B-Cell-Specific Myd88 L252P Expression Causes a Premalignant Gammopathy Resembling IgM MGUS

A highly recurrent somatic L265P mutation in the TIR domain of the signaling adapter MYD88 constitutively activates NF-κB. It occurs in nearly all human patients with Waldenström’s macroglobulinemia (WM), a B cell malignancy caused by IgM-expressing cells. Here, we introduced an inducible leucine to...

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Detalles Bibliográficos
Autores principales: Schmidt, Kristin, Sack, Ulrike, Graf, Robin, Winkler, Wiebke, Popp, Oliver, Mertins, Philipp, Sommermann, Thomas, Kocks, Christine, Rajewsky, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747680/
https://www.ncbi.nlm.nih.gov/pubmed/33343574
http://dx.doi.org/10.3389/fimmu.2020.602868

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