Nonhuman primate to human immunobridging to infer the protective effect of an Ebola virus vaccine candidate

It has been proven challenging to conduct traditional efficacy trials for Ebola virus (EBOV) vaccines. In the absence of efficacy data, immunobridging is an approach to infer the likelihood of a vaccine protective effect, by translating vaccine immunogenicity in humans to a protective effect, using...

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Detalles Bibliográficos
Autores principales: Roozendaal, Ramon, Hendriks, Jenny, van Effelterre, Thierry, Spiessens, Bart, Dekking, Liesbeth, Solforosi, Laura, Czapska-Casey, Dominika, Bockstal, Viki, Stoop, Jeroen, Splinter, Daniel, Janssen, Sarah, Baelen, Ben van, Verbruggen, Nadia, Serroyen, Jan, Dekeyster, Eline, Volkmann, Ariane, Wollmann, Yvonne, Carrion, Ricardo, Giavedoni, Luis D., Robinson, Cynthia, Leyssen, Maarten, Douoguih, Macaya, Luhn, Kerstin, Pau, Maria Grazia, Sadoff, Jerry, Vandebosch, An, Schuitemaker, Hanneke, Zahn, Roland, Callendret, Benoit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747701/
https://www.ncbi.nlm.nih.gov/pubmed/33335092
http://dx.doi.org/10.1038/s41541-020-00261-9

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