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Quantile-specific heritability of sibling leptin concentrations and its implications for gene-environment interactions
“Quantile-dependent expressivity” occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g., leptin) is high or low relative to its distribution. Leptin concentrations are strongly related to adiposity, whose heritability is quantile dependent. Whether inheritance of...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747738/ https://www.ncbi.nlm.nih.gov/pubmed/33335207 http://dx.doi.org/10.1038/s41598-020-79116-1 |