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Intratumor Heterogeneity Correlates With Reduced Immune Activity and Worse Survival in Melanoma Patients

BACKGROUND: Human malignant melanoma is a highly aggressive, heterogeneous and drug-resistant cancer. Due to a high number of clones, harboring various mutations that affect key pathways, there is an exceptional level of phenotypic variation and intratumor heterogeneity (ITH) in melanoma. This poses...

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Detalles Bibliográficos
Autores principales:	Lin, Zhen, Meng, Xianyi, Wen, Jinming, Corral, José María, Andreev, Darja, Kachler, Katerina, Schett, Georg, Chen, Xiaoxiang, Bozec, Aline
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747763/ https://www.ncbi.nlm.nih.gov/pubmed/33344244 http://dx.doi.org/10.3389/fonc.2020.596493

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