Selective activity of diselenides against Aedes aegypti (Diptera: Culicidae) larvae

INTRODUCTION: Aedes aegypti (L.) is the major vector of arboviruses that causes serious public health concerns in tropical and subtropical countries. METHODS: We examined the larvicidal activity of 1,2-diphenyldiselenide [(PhSe)(2)] and 1,2-bis(4-chlorophenyl) diselenide [(p-ClPhSe)(2)] and determin...

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Detalles Bibliográficos
Autores principales: Targanski, Sabrina Ketrin, Sousa, Janaina Rosa, Stein, André Luiz Agnes, Soares, Marcos Antônio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747817/
https://www.ncbi.nlm.nih.gov/pubmed/33338117
http://dx.doi.org/10.1590/0037-8682-0146-2020
Descripción
Sumario:INTRODUCTION: Aedes aegypti (L.) is the major vector of arboviruses that causes serious public health concerns in tropical and subtropical countries. METHODS: We examined the larvicidal activity of 1,2-diphenyldiselenide [(PhSe)(2)] and 1,2-bis(4-chlorophenyl) diselenide [(p-ClPhSe)(2)] and determine its toxicity to different non-target organisms. RESULTS: (PhSe)(2) and (p-ClPhSe)(2) killed Ae. aegypti L3 larvae with LC(50/24h) values of 65.63 µM (20.48 mg/L) and 355.19 µM (135.33 mg/L), respectively. (PhSe)(2) was not toxic to the four model organisms. CONCLUSIONS: (PhSe)(2) is a larvicidal compound with selective action against Ae. aegypti larvae. The mechanisms of action of (PhSe)(2) under field conditions remain to be investigated.

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