First report of a bla(NDM)-resistant gene in a Klebsiella aerogenes clinical isolate from Brazil

INTRODUCTION: Carbapenemase-resistant enterobacteria that produce the bla (NDM) gene are found worldwide. However, this is the first report of bla(NDM) in Klebsiella aerogenes in Brazil. METHODS: The identification of bacterial species was performed using anautomated system and confirmed by biochemi...

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Autores principales: Soares, Cynthia Regina Pedrosa, Oliveira-Júnior, Jorge Belém, Firmo, Elza Ferreira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747820/
https://www.ncbi.nlm.nih.gov/pubmed/33338110
http://dx.doi.org/10.1590/0037-8682-0262-2020
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author Soares, Cynthia Regina Pedrosa
Oliveira-Júnior, Jorge Belém
Firmo, Elza Ferreira
author_facet Soares, Cynthia Regina Pedrosa
Oliveira-Júnior, Jorge Belém
Firmo, Elza Ferreira
author_sort Soares, Cynthia Regina Pedrosa
collection PubMed
description INTRODUCTION: Carbapenemase-resistant enterobacteria that produce the bla (NDM) gene are found worldwide. However, this is the first report of bla(NDM) in Klebsiella aerogenes in Brazil. METHODS: The identification of bacterial species was performed using anautomated system and confirmed by biochemical tests, 16S rRNA gene sequencing, and detection of resistance genes. RESULTS: The clinical isolate showed minimum inhibitory concentration resistance to meropenem and polymyxin B at 8mg/L and 4mg/L, respectively. Only the bla(NDM) gene was detected. CONCLUSIONS: The current report of the bla(NDM) gene in isolated MDR enterobacteria indicates that this gene can spread silently in a hospital setting.
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spelling pubmed-77478202020-12-22 First report of a bla(NDM)-resistant gene in a Klebsiella aerogenes clinical isolate from Brazil Soares, Cynthia Regina Pedrosa Oliveira-Júnior, Jorge Belém Firmo, Elza Ferreira Rev Soc Bras Med Trop Short Communication INTRODUCTION: Carbapenemase-resistant enterobacteria that produce the bla (NDM) gene are found worldwide. However, this is the first report of bla(NDM) in Klebsiella aerogenes in Brazil. METHODS: The identification of bacterial species was performed using anautomated system and confirmed by biochemical tests, 16S rRNA gene sequencing, and detection of resistance genes. RESULTS: The clinical isolate showed minimum inhibitory concentration resistance to meropenem and polymyxin B at 8mg/L and 4mg/L, respectively. Only the bla(NDM) gene was detected. CONCLUSIONS: The current report of the bla(NDM) gene in isolated MDR enterobacteria indicates that this gene can spread silently in a hospital setting. Sociedade Brasileira de Medicina Tropical - SBMT 2020-12-21 /pmc/articles/PMC7747820/ /pubmed/33338110 http://dx.doi.org/10.1590/0037-8682-0262-2020 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
Soares, Cynthia Regina Pedrosa
Oliveira-Júnior, Jorge Belém
Firmo, Elza Ferreira
First report of a bla(NDM)-resistant gene in a Klebsiella aerogenes clinical isolate from Brazil
title First report of a bla(NDM)-resistant gene in a Klebsiella aerogenes clinical isolate from Brazil
title_full First report of a bla(NDM)-resistant gene in a Klebsiella aerogenes clinical isolate from Brazil
title_fullStr First report of a bla(NDM)-resistant gene in a Klebsiella aerogenes clinical isolate from Brazil
title_full_unstemmed First report of a bla(NDM)-resistant gene in a Klebsiella aerogenes clinical isolate from Brazil
title_short First report of a bla(NDM)-resistant gene in a Klebsiella aerogenes clinical isolate from Brazil
title_sort first report of a bla(ndm)-resistant gene in a klebsiella aerogenes clinical isolate from brazil
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747820/
https://www.ncbi.nlm.nih.gov/pubmed/33338110
http://dx.doi.org/10.1590/0037-8682-0262-2020
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