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Identification of nuclear export signal in KLLN suggests potential role in proteasomal degradation in cancer cells

Germline and somatic promoter hypermethylation of KLLN has been found in diverse heritable and sporadic cancers, respectively. KLLN has many identified tumor suppressor functions, and when first reported, was thought to be exclusively nuclear. Here, we report on KLLN localization in both the nucleus...

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Detalles Bibliográficos
Autores principales: Sankunny, Madhav, Eng, Charis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747863/
https://www.ncbi.nlm.nih.gov/pubmed/33400740
http://dx.doi.org/10.18632/oncotarget.27833