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Targeted Delivery of Curcumin to Polyethylene-Induced Osteolysis by Magnetically Guided Zoledronate-Anchored Poly Lactic-Co-Glycolic Acid Nanoparticles via Repressing NF-κB Signaling

Aseptic loosening induced by periprosthetic osteolysis (PPO) is the leading complication of total joint arthroplasty (TJA) and results in patients having to receive revision surgery. However, there is still no efficient drug to prevent or even slow the pathological process. Herein, we report novel d...

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Autores principales: Li, Jingyi, Niu, Chengcheng, Jiang, Zichao, Zhang, Zhen, Pan, Yixiao, Xing, Qiqi, Guo, Qi, An, Senbo, Hu, Yihe, Wang, Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747869/
https://www.ncbi.nlm.nih.gov/pubmed/33343370
http://dx.doi.org/10.3389/fphar.2020.600156
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author Li, Jingyi
Niu, Chengcheng
Jiang, Zichao
Zhang, Zhen
Pan, Yixiao
Xing, Qiqi
Guo, Qi
An, Senbo
Hu, Yihe
Wang, Long
author_facet Li, Jingyi
Niu, Chengcheng
Jiang, Zichao
Zhang, Zhen
Pan, Yixiao
Xing, Qiqi
Guo, Qi
An, Senbo
Hu, Yihe
Wang, Long
author_sort Li, Jingyi
collection PubMed
description Aseptic loosening induced by periprosthetic osteolysis (PPO) is the leading complication of total joint arthroplasty (TJA) and results in patients having to receive revision surgery. However, there is still no efficient drug to prevent or even slow the pathological process. Herein, we report novel dual-targeted, curcumin-loaded Poly lactic-co-glycolic acid nanoparticles (ZSCNPs) to inhibit polyethylene-induced osteolysis. These ZSCNPs have good biocompatibility and excellent bone binding affinity. Under external magnetic field guidance, the ZSCNPs can specifically target osteolytic sites with sustained curcumin release, efficiently suppress the effect of IκB kinase, subsequently inhibit activation of the nuclear factor-kappa B (NF-κB) signaling pathway, and ultimately prevent osteoclast formation and particle-induced osteolysis. Therefore, these novel dual-targeted, drug-loaded nanoparticles could be applied as a useful strategy for targeted treatment of PPO after TJA.
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spelling pubmed-77478692020-12-19 Targeted Delivery of Curcumin to Polyethylene-Induced Osteolysis by Magnetically Guided Zoledronate-Anchored Poly Lactic-Co-Glycolic Acid Nanoparticles via Repressing NF-κB Signaling Li, Jingyi Niu, Chengcheng Jiang, Zichao Zhang, Zhen Pan, Yixiao Xing, Qiqi Guo, Qi An, Senbo Hu, Yihe Wang, Long Front Pharmacol Pharmacology Aseptic loosening induced by periprosthetic osteolysis (PPO) is the leading complication of total joint arthroplasty (TJA) and results in patients having to receive revision surgery. However, there is still no efficient drug to prevent or even slow the pathological process. Herein, we report novel dual-targeted, curcumin-loaded Poly lactic-co-glycolic acid nanoparticles (ZSCNPs) to inhibit polyethylene-induced osteolysis. These ZSCNPs have good biocompatibility and excellent bone binding affinity. Under external magnetic field guidance, the ZSCNPs can specifically target osteolytic sites with sustained curcumin release, efficiently suppress the effect of IκB kinase, subsequently inhibit activation of the nuclear factor-kappa B (NF-κB) signaling pathway, and ultimately prevent osteoclast formation and particle-induced osteolysis. Therefore, these novel dual-targeted, drug-loaded nanoparticles could be applied as a useful strategy for targeted treatment of PPO after TJA. Frontiers Media S.A. 2020-12-04 /pmc/articles/PMC7747869/ /pubmed/33343370 http://dx.doi.org/10.3389/fphar.2020.600156 Text en Copyright © 2020 Li, Niu, Jiang, Zhang, Pan, Xing, Guo, An, Hu and Wang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Li, Jingyi
Niu, Chengcheng
Jiang, Zichao
Zhang, Zhen
Pan, Yixiao
Xing, Qiqi
Guo, Qi
An, Senbo
Hu, Yihe
Wang, Long
Targeted Delivery of Curcumin to Polyethylene-Induced Osteolysis by Magnetically Guided Zoledronate-Anchored Poly Lactic-Co-Glycolic Acid Nanoparticles via Repressing NF-κB Signaling
title Targeted Delivery of Curcumin to Polyethylene-Induced Osteolysis by Magnetically Guided Zoledronate-Anchored Poly Lactic-Co-Glycolic Acid Nanoparticles via Repressing NF-κB Signaling
title_full Targeted Delivery of Curcumin to Polyethylene-Induced Osteolysis by Magnetically Guided Zoledronate-Anchored Poly Lactic-Co-Glycolic Acid Nanoparticles via Repressing NF-κB Signaling
title_fullStr Targeted Delivery of Curcumin to Polyethylene-Induced Osteolysis by Magnetically Guided Zoledronate-Anchored Poly Lactic-Co-Glycolic Acid Nanoparticles via Repressing NF-κB Signaling
title_full_unstemmed Targeted Delivery of Curcumin to Polyethylene-Induced Osteolysis by Magnetically Guided Zoledronate-Anchored Poly Lactic-Co-Glycolic Acid Nanoparticles via Repressing NF-κB Signaling
title_short Targeted Delivery of Curcumin to Polyethylene-Induced Osteolysis by Magnetically Guided Zoledronate-Anchored Poly Lactic-Co-Glycolic Acid Nanoparticles via Repressing NF-κB Signaling
title_sort targeted delivery of curcumin to polyethylene-induced osteolysis by magnetically guided zoledronate-anchored poly lactic-co-glycolic acid nanoparticles via repressing nf-κb signaling
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747869/
https://www.ncbi.nlm.nih.gov/pubmed/33343370
http://dx.doi.org/10.3389/fphar.2020.600156
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